ArticleNeurobiology of aging2022
APOE4 homozygote females are resistant to the beneficial effects of 17β-estradiol on memory and CA1 dendritic spine density in the EFAD mouse model of Alzheimer's disease.
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Article in Neurobiology of aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Estradiol and memory circuitry in the postmenopause: Modification by APOE4.Research square · 2026Article
- APOE4 negates the effects of ovarian hormones on cerebrovascular endothelial and mitochondrial function.The Journal of physiology · 2026Article
- The complex of gut microbial metabolites and sex hormones in Alzheimer's disease.Seminars in immunopathology · 2026Review
- Not your mother's hormone therapy: Highly selective estrogen receptor beta agonists as next-generation therapies for menopausal symptom relief.Hormones and behavior · 2025Review
- Protection against APOE4-associated phenotypes with the longevity-promoting intervention 17α-estradiol in middle-aged male mice.Communications medicine · 2025Article
- One size does not fit all: how type of menopause and hormone therapy matters for brain health.The British journal of psychiatry : the journal of mental science · 2025Review
- What Can We Learn About Alzheimer's Disease from People with Down Syndrome?Current topics in behavioral neurosciences · 2025Review
- Estrogen, menopause, and Alzheimer's disease: understanding the link to cognitive decline in women.Frontiers in molecular biosciences · 2025Review
- Regulation of the blood-brain barrier function by peripheral cues in health and disease.Metabolic brain disease · 2024Review
- Apolipoprotein E polymorphisms and female fertility in a transgenic mouse model of Alzheimer's disease.Scientific reports · 2024Article
- G protein-coupled estrogen receptor (GPER) in the dorsal hippocampus regulates memory consolidation in gonadectomized male mice, likely via different signaling mechanisms than in female mice.Hormones and behavior · 2024Article
- Associations of endogenous estrogens, plasma Alzheimer's disease biomarkers, andFrontiers in aging neuroscience · 2024Article
- Effects of obesogenic diet and 17β-estradiol in female mice withFrontiers in aging neuroscience · 2024Article
- The novel estrogen receptor beta agonist EGX358 andFrontiers in aging neuroscience · 2024Article
- Estrogen receptor beta in astrocytes modulates cognitive function in mid-age female mice.Nature communications · 2023Article
- Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potentiation in the Prefrontal Cortex of Female APPswe/PS1dE9 Mice Modelling Alzheimer's Disease.International journal of molecular sciences · 2023Article
- A how-to guide for a precision medicine approach to the diagnosis and treatment of Alzheimer's disease.Frontiers in aging neuroscience · 2023Review
- Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome.Brain communications · 2023Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Lisa R TaxierDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee WI, USA.
Sarah M PhilippiDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee WI, USA; Current affiliation: Department of Neuroscience and Neuroscience Program, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Aaron W FleischerDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee WI, USA.
Jason M YorkDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Mary Jo LaDuDepartment of Anatomy and Cell Biology, University of Illinois at Chicago, Chicago, IL, USA.
Karyn M FrickDepartment of Psychology, University of Wisconsin-Milwaukee, Milwaukee WI, USA. Electronic address: frickk@uwm.edu.
University of Wisconsin–Milwaukee · USUniversity of Illinois Chicago · US
Funding
R01 Estrogen therapy and APOE4 risk in Alzheimer's tested in female EFAD miceR01AG057008 · NIA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADU, MARY JO, THATCHER, GREGORY R. J · 2017 to 2020
$2.5MMechanisms underlying memory regulation by 17beta-estradiol, canonical Wnt signaling, and BDNF in male and female miceR01MH107886 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI FRICK, KARYN M · 2016 to 2020
$1.9MCharacterization of protective roles of ApoE2 against aging and Alzheimer's diseaseR56AG058655 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI CAI, DONGMING, LADU, MARY JO · 2019 to 2019
$841kDevelopment of ER-beta Agonists to Treat Post-Menopausal Memory DeclineR15GM118304 · NIGMS · CONCORDIA UNIVERSITY WISCONSIN · PI SEM, DANIEL S · 2015 to 2018
$820kAged EFAD mice as a model for the effects of APOE and sex on AD pathologyUH3NS100127 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADU, MARY JO · 2018 to 2020
$714kAged EFAD mice as a model for the effects of APOE and sex on AD pathologyUH2NS100127 · NINDS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LADU, MARY JO · 2016 to 2017
$239kThe role of hippocampal astrocytes in memory and estrogenic regulation of memoryF31MH118822 · NIMH · UNIVERSITY OF WISCONSIN MILWAUKEE · PI TAXIER, LISA R · 2019 to 2021
$119kNIA NIH HHS R01 AG057008NIA NIH HHS R56 AG058655NIGMS NIH HHS R15 GM118304NIMH NIH HHS F31 MH118822NIMH NIH HHS R01 MH107886NINDS NIH HHS UH2 NS100127NINDS NIH HHS UH3 NS100127
Abstract
Female APOE4 carriers are at greatest risk of Alzheimer's disease (AD). The potent estrogen 17β-estradiol (E
Indexed as
Alzheimer DiseaseApolipoprotein E4AnimalsApolipoprotein E3Dendritic SpinesDisease Models, AnimalEstradiolEstrogensFemaleHomozygoteMiceMice, TransgenicApolipoprotein E3Apolipoprotein E4EstradiolEstrogens17β-estradiolAlzheimer's diseaseAPOE4Apolipoprotein EHippocampusMedial prefrontal cortexObject recognitionSpatial memory
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