ArticleJournal of orthopaedic surgery and research2022
Ozone induces autophagy by activating PPARγ/mTOR in rat chondrocytes treated with IL-1β.
Article in Journal of orthopaedic surgery and research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.
- Ozone injections reduce pain in knee osteoarthritis: a systematic review and meta-analysis.Medical gas research · 2026Pooled it
- Impact of oxygen-ozone mixture on cellular functions: a biochemical perspective across cell types.Molecular medicine (Cambridge, Mass.) · 2026Review
- Intra-Articular Ozone Injections for Temporomandibular Joint Disorders: A Systematic Review.Journal of clinical medicine · 2026Review
- Low ozone concentrations promoteEuropean journal of histochemistry : EJH · 2026Article
- Therapeutic Targeting of PPARγ in Nonalcoholic Fatty Liver Disease: Efficacy, Safety, and Drug Development.Drug design, development and therapy · 2025Review
- Low-Dose Ozone as a Eustress Inducer: Experimental Evidence of the Molecular Mechanisms Accounting for Its Therapeutic Action.International journal of molecular sciences · 2024Review
- Ozone therapy in musculoskeletal medicine: a comprehensive review.European journal of medical research · 2024Review
- Osteoarthritis: Role of Peroxisome Proliferator-Activated Receptors.International journal of molecular sciences · 2023Review
- Strategies for the Management of Spike Protein-Related Pathology.Microorganisms · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOsteoarthritis (OA) is the main cause of older pain and disability. Intra-articular injections of ozone (O
methodsPrimary chondrocytes were isolated from Wistar rats cartilage within 3 days. The OA chondrocytes model was induced via treatment with IL-1β for 24 h. Then the cells were treated with O
results30 μg/ml O
conclusions30 μg/ml O
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.