ArticleMicrobial cell factories2022
Efficient molasses utilization for low-molecular-weight poly-γ-glutamic acid production using a novel Bacillus subtilis stain.
Article in Microbial cell factories, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Efficient Ammonium Nitrogen Metabolization and γ-PGA Production byMicroorganisms · 2026Article
- Metabolomic insights into glutamate-induced γ-PGA biosynthesis and process optimization in Bacillus subtilis SCP017-03 for scalable production.Bioprocess and biosystems engineering · 2025Article
- Efficient production of poly-γ-glutamic acid using computational fluid dynamics simulations byFood chemistry: X · 2025Article
- Microbial production and functional assessment ofFrontiers in microbiology · 2025Article
- Enhanced Poly-γ-Glutamic Acid Production by a Newly Isolated Bacillus halotolerans F29.Journal of microbiology (Seoul, Korea) · 2024Article
- Molecular weight control of poly-γ-glutamic acid reveals novel insights into extracellular polymeric substance synthesis in Bacillus licheniformis.Biotechnology for biofuels and bioproducts · 2024Article
- Synthesis of Poly-γ-Glutamic Acid and Its Application in Biomedical Materials.Materials (Basel, Switzerland) · 2023Review
- Production of Tetramethylpyrazine from Cane Molasses byMolecules (Basel, Switzerland) · 2023Article
- Effects of FeMicrobial cell factories · 2023Article
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Authors and funding
7 authors.
Funding
Abstract
backgroundPoly-γ-glutamic acid (γ-PGA) is a biopolymer and has various applications based on its biocompatibility, non-toxicity, and edibility. Low-molecular-weight (Mw)-γ-PGA has promising applications in agriculture and pharmaceuticals. It is traditionally produced by enzymatic hydrolysis. Cost-effective bioproduction of low-Mw-γ-PGA is essential for commercial application of γ-PGA.
resultsBacillus subtilis 242 is a newly isolated low-Mw-γ-PGA-producing strain. To develop cost-effective production of γ-PGA using this newly isolated strain, cane molasses and corn steep liquor were used to produce γ-PGA. The concentration of cane molasses was optimized and 100 g/L cane molasses resulted in high γ-PGA production. The effects of yeast extract and corn steep liquor on γ-PGA yield were investigated. High concentration of γ-PGA was obtained in the medium with corn steep liquor. A concentration of 32.14 g/L γ-PGA was achieved in fed-batch fermentation, with a productivity of 0.67 g/L/h and a percentage yield (g
conclusionThis study demonstrated the potential application of B. subtilis 242 for cost-effective production of low-Mw-γ-PGA from cane molasses.
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