ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022
Predictors of health-related quality of life in Parkinson's disease: the impact of overlap between health-related quality of life and clinical measures.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Assessments scales for the evaluation of health-related quality of life in Parkinson's disease, progressive supranuclear palsy, and multiple system atrophy: a systematic review.Frontiers in psychology · 2024Pooled it
- Home physical therapy versus telerehabilitation in improving motor function and quality of life in Parkinson's disease: a randomized controlled trial.BMC geriatrics · 2024Trial
- Eight-year longitudinal changes in functional connectivity of the fatigue network in Parkinson's disease: evidence from four timepoints.Brain imaging and behavior · 2026Article
- Spermidine Suppresses Peripheral Inflammation and Alleviates Non-Motor Symptoms in the 6-OHDA-Induced Rat Model of Parkinson's Disease.Molecules (Basel, Switzerland) · 2026Article
- Multidimensional factors of health-related quality of life in parkinson's disease using ensemble learning and network analysis.Scientific reports · 2025Article
- Quantity and quality of care and staff knowledge regarding people with Parkinson's disease in long-term nursing care: "real-life" results from the German Care4PD study.Frontiers in aging neuroscience · 2025Article
- A comparative analysis of health-related and individual quality of life in people with Parkinson's disease.Frontiers in neurology · 2025Article
- Hypoxia Pathways in Parkinson's Disease: From Pathogenesis to Therapeutic Targets.International journal of molecular sciences · 2024Review
- Psychometric properties of Arabic-translated-related quality of life scales for people with parkinson disease: a scoping review.BMC public health · 2024Article
- Factors associated with self-rated health in people with late-stage parkinson's and cognitive impairment.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024Article
- Interpretable video-based tracking and quantification of parkinsonism clinical motor states.NPJ Parkinson's disease · 2024Article
- Hypoxia Sensing and Responses in Parkinson's Disease.International journal of molecular sciences · 2024Review
- Cognitive and emotional predictors of quality of life and functioning after COVID-19.Annals of clinical and translational neurology · 2024Article
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9 authors.
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Abstract
purposeThis study aimed to determine predictors of health-related quality of life (HRQoL) in Parkinson's disease (PD) and to explore their predictive value before and after controlling overlapping items between HRQoL and clinical variables.
methodsOne hundred and eight PD patients underwent motor, anxiety, depression, apathy, fatigue, and neurocognition assessment. HRQoL was assessed by the Parkinson's Disease Questionnaire-39 (PDQ-39). In order to determine predictors of HRQoL in PD, stepwise multiple regression analyses were performed in two ways: before and after removing the emotional well-being dimension from PDQ-39 to control the overlap between depression and anxiety, and HRQoL.
resultsHRQoL total index was predicted by anxiety, fatigue, motor symptoms, and depression, explaining 26.9%, 7.2%, 2.8%, and 1.9% of the variance. However, after removing overlapping items, HRQoL total index was predicted by fatigue (16.5%), anxiety (6.1%), motor symptoms (3.9%), and neurocognition (2.5%), but not depression. Regarding HRQoL dimensions, mobility and activities of daily living were predicted by fatigue (19.7% and 5%) and UPDRS-III (4% and 10.2%); emotional well-being by fatigue (7.9%); social support by anxiety (12.2%) and UPDRS-III (8.6%); communication by neurocognition (5.3%) and UPDRS-III (3.4%); cognition by anxiety (10.6%) and bodily discomfort by anxiety (23%) and fatigue (4.1%).
conclusionThese findings showed the importance of identifying and controlling overlapping items of HRQoL and clinical measures to perform an accurate interpretation. HRQoL dimensions showed different predictors before and after controlling the overlap. Based on these results fatigue, anxiety, motor symptoms, and neurocognition, but not depression are the main predictors of HRQoL in PD patients.
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