ArticleCommunications biology2022
Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Ancient regulatory evolution shapes individual language abilities in present-day humans.Science advances · 2026Article
- Rare-variant aggregation highlights disease-linked genes associated with brain volume variation.American journal of human genetics · 2026Article
- The genetic architecture of human cerebellar morphology supports a key role for the cerebellum in human evolution and psychopathology.Communications biology · 2026Article
- Ancient regulatory evolution shapes individual language abilities in present-day humans.bioRxiv : the preprint server for biology · 2026Article
- Polygenic Associations Between Motor Behavior, Neuromotor Traits, and Active Music Engagement in Four Cohorts.Annals of the New York Academy of Sciences · 2026Article
- GWAS for behavioral traits in golden retrievers identifies genes implicated in human temperament, mental health, and cognition.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Genetics of Cerebellar Structure and Associations With Cognitive Performance: A Twin Magnetic Resonance Imaging Study.Human brain mapping · 2025Article
- Strawberry notch 1 safeguards neuronal genome via regulation of Yeats4 expression.Cell death discovery · 2025Article
- Precision neurodiversity: personalized brain network architecture as a window into cognitive variability.Frontiers in human neuroscience · 2025Review
- Insights into the genetic architecture of cerebellar lobules derived from the UK Biobank.Scientific reports · 2024Article
- Abundant pleiotropy across neuroimaging modalities identified through a multivariate genome-wide association study.Nature communications · 2024Article
- Lung development genes, adult lung function and cognitive traits.Brain communications · 2024Article
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9 authors.
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Abstract
Cerebellar volume is highly heritable and associated with neurodevelopmental and neurodegenerative disorders. Understanding the genetic architecture of cerebellar volume may improve our insight into these disorders. This study aims to investigate the convergence of cerebellar volume genetic associations in close detail. A genome-wide associations study for cerebellar volume was performed in a discovery sample of 27,486 individuals from UK Biobank, resulting in 30 genome-wide significant loci and a SNP heritability of 39.82%. We pinpoint the likely causal variants and those that have effects on amino acid sequence or cerebellar gene-expression. Additionally, 85 genome-wide significant genes were detected and tested for convergence onto biological pathways, cerebellar cell types, human evolutionary genes or developmental stages. Local genetic correlations between cerebellar volume and neurodevelopmental and neurodegenerative disorders reveal shared loci with Parkinson's disease, Alzheimer's disease and schizophrenia. These results provide insights into the heritable mechanisms that contribute to developing a brain structure important for cognitive functioning and mental health.
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