Evidence map›Paper›PMID 35842440›Full record

ArticleScientific reports2022

C698R mutation in Lrsam1 gene impairs nerve regeneration in a CMT2P mouse model.

Daniel Moiseev, Zafar Wazir, Donghao Liu, Jun Li, Bo Hu

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 63% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Daniel MoiseevDepartment of Neurology, Wayne State University School of Medicine, Detroit, MI, USA.
Zafar WazirDepartment of Neurology, Wayne State University School of Medicine, Detroit, MI, USA.
Donghao LiuDepartment of Neurology, Wayne State University School of Medicine, Detroit, MI, USA.
Jun LiDepartment of Neurology, Wayne State University School of Medicine, Detroit, MI, USA.
Bo HuDepartment of Neurology, Wayne State University School of Medicine, Detroit, MI, USA. bhu@houstonmethodist.org.
Wayne State University · USJohn D. Dingell VA Medical Center · US

Funding

Myelin Junction Therapy in Peripheral NeuropathiesR01NS115748 · NINDS · WAYNE STATE UNIVERSITY · PI LI, JUN · 2020 to 2024
$1.9M
Therapeutic Development in Segmental DemyelinationI01BX003385 · VA · VETERANS HEALTH ADMINISTRATION · PI LI, JUN · 2016 to 2020
–
BLRD VA I01 BX003385NINDS NIH HHS R01 NS115748NINDS NIH HHS R01NS115748VA IBX003385A
6 · The paper itself

Abstract

Missense mutation C694R in the RING domain of the LRSAM1 gene results in a dominantly inherited polyneuropathy, Charcot-Marie-Tooth disease type 2P (CMT2P). We have generated and characterized a Lrsam1

Indexed as

Charcot-Marie-Tooth DiseaseAnimalsDisease Models, AnimalDNA HelicasesHumansMiceMutationNerve RegenerationNeural ConductionPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsSciatic NerveUbiquitin-Protein LigasesDNA HelicasesG3BP1 protein, humanLRSAM1 protein, humanLRSAM1 protein, mousePoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif ProteinsUbiquitin-Protein Ligases

Identifiers

PMID35842440
PMCPMC9288509
OpenAlexW4285587960

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.