Evidence map›Paper›PMID 35842184›Full record

ReviewPharmacological research2022

Perivascular adipose tissue in autoimmune rheumatic diseases.

Hong Shi, Hanping Wu, Michael A Winkler, Eric J Belin de Chantemèle, Richard Lee, Ha Won Kim, Neal L Weintraub

Open access · hybridAbstract readReview
In one paragraph

Review in Pharmacological research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Multi-Modality Imaging in Cardio-Rheumatology.Current cardiology reports · 2025
    Review
  8. Perivascular Adipose Tissue Becomes Pro-Contractile and Remodels in an IL10International journal of molecular sciences · 2024
    Article
  9. Review
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hong ShiDivision of Rheumatology, Medical College of Georgia at Augusta University, Augusta, GA, USA; Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Hanping WuDepartment of Radiology and Imaging, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Michael A WinklerDepartment of Radiology and Imaging, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Eric J Belin de ChantemèleDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA; Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Richard LeeDepartment of Surgery, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Ha Won KimDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA; Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Neal L WeintraubDivision of Cardiology, Department of Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA; Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA. Electronic address: nweintraub@augusta.edu.
Augusta University · US

Funding

The Adipocyte PPARgama/Adiponectin Axis and Alzheimer's DiseaseRF1AG062166 · NIA · AUGUSTA UNIVERSITY · PI LU, XIN-YUN · 2019 to 2019
$3.5M
Innovative Approaches to Treat Duchenne Muscular Dystrophy Using iPSC-Derived Muscle ProgenitorsR01AR070029 · NIAMS · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2021
$2.6M
Notch1/miR-322 Axis in Stem Cell Mediated Vascular RepairR01HL134354 · NHLBI · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2020
$2.5M
Mechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysmR01HL142097 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2018 to 2021
$2.1M
Perivascular adipose tissue and vascular remodelingR01HL112640 · NHLBI · UNIVERSITY OF CINCINNATI · PI WEINTRAUB, NEAL L · 2012 to 2016
$2.1M
Epigenetic regulation of HDAC9 in obesity and atherosclerosisR01HL126949 · NHLBI · AUGUSTA UNIVERSITY · PI WEINTRAUB, NEAL L · 2016 to 2019
$1.8M
HDAC9, Aging and Alzheimer's DiseaseR56AG064895 · NIA · AUGUSTA UNIVERSITY · PI LU, XIN-YUN, WEINTRAUB, NEAL L · 2019 to 2020
$1.5M
NHLBI NIH HHS R01 HL112640NHLBI NIH HHS R01 HL126949NHLBI NIH HHS R01 HL134354NHLBI NIH HHS R01 HL142097NIAMS NIH HHS R01 AR070029NIA NIH HHS R56 AG064895NIA NIH HHS RF1 AG062166
6 · The paper itself

Abstract

Perivascular adipose tissue (PVAT) resides at the outermost boundary of the vascular wall, surrounding most conduit blood vessels, except for the cerebral vessels, in humans. A growing body of evidence suggests that inflammation localized within PVAT may contribute to the pathogenesis of cardiovascular disease (CVD). Patients with autoimmune rheumatic diseases (ARDs), e.g., systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), psoriasis, etc., exhibit heightened systemic inflammation and are at increased risk for CVD. Data from clinical studies in patients with ARDs support a linkage between dysfunctional adipose tissue, and PVAT in particular, in disease pathogenesis. Here, we review the data linking PVAT to the pathogenesis of CVD in patients with ARDs, focusing on the role of novel PVAT imaging techniques in defining disease risk and responses to biological therapies.

Indexed as

Autoimmune DiseasesCardiovascular DiseasesRespiratory Distress SyndromeRheumatic DiseasesAdipose TissueHumansInflammationAutoimmune rheumatic diseaseCardiovascular diseaseInflammationPerivascular adipose tissue

Identifiers

PMID35842184
PMCPMC10184774
OpenAlexW4285404876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.