Evidence map›Paper›PMID 35842100›Full record

ArticleNeuroImage2022

BOLD cofluctuation 'events' are predicted from static functional connectivity.

Zach Ladwig, Benjamin A Seitzman, Ally Dworetsky, Yuhua Yu, Babatunde Adeyemo, Derek M Smith, Steven E Petersen, Caterina Gratton

Open access · goldAbstract read
In one paragraph

Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The individuality of single-frame functional brain connectivity.bioRxiv : the preprint server for biology · 2026
    Article
  5. Variation in high-amplitude events across the human lifespan.Network neuroscience (Cambridge, Mass.) · 2026
    Article
  6. Article
  7. Switching Patterns of Cortical-Subcortical Interaction in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Human brain state dynamics reflect individual neuro-phenotypes.bioRxiv : the preprint server for biology · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Living on the edge: network neuroscience beyond nodes.Trends in cognitive sciences · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Zach LadwigInterdepartmental Neuroscience Program, Northwestern University.
Benjamin A SeitzmanDepartment of Radiation Oncology, Washington University St. Louis School of Medicine.
Ally DworetskyDepartment of Psychology, Northwestern University.
Yuhua YuDepartment of Psychology, Northwestern University.
Babatunde AdeyemoDepartment of Neurology, Washington University St. Louis School of Medicine.
Derek M SmithDepartment of Neurology, Division of Cognitive Neurology/Neuropsychology, The Johns Hopkins University School of Medicine.
Steven E PetersenDepartment of Radiology, Washington University St. Louis School of Medicine; Department of Neurology, Washington University St. Louis School of Medicine; Department of Psychological and Brain Sciences, Washington University St. Louis School of Medicine; Department of Neuroscience, Washington University St. Louis School of Medicine; Department of Biomedical Engineering, Washington University St. Louis School of Medicine.
Caterina GrattonInterdepartmental Neuroscience Program, Northwestern University; Department of Psychology, Northwestern University; Department of Neurology, Northwestern University. Electronic address: caterina.gratton@northwestern.edu.
Washington University in St. Louis · USJohns Hopkins University · USNorthwestern University · US

Funding

Research Education Core FP30AG072977 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR · 2021 to 2026
$26.3M
TRAINING PROGRAM IN THE NEUROSCIENCE OF HUMAN COGNITIONT32NS047987 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Rodrigo M Braga, Christina Maria Zelano · 2006 to 2026
$5.6M
Sources and Functional Consequences of Individual Differences in Human Functional Brain Networks Related to Controlled BehaviorR01MH118370 · NIMH · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI GRATTON, CATERINA · 2019 to 2023
$3.4M
NIA NIH HHS P30 AG072977NIMH NIH HHS R01 MH118370NINDS NIH HHS T32 NS047987
6 · The paper itself

Abstract

Recent work identified single time points ("events") of high regional cofluctuation in functional Magnetic Resonance Imaging (fMRI) which contain more large-scale brain network information than other, low cofluctuation time points. This suggested that events might be a discrete, temporally sparse signal which drives functional connectivity (FC) over the timeseries. However, a different, not yet explored possibility is that network information differences between time points are driven by sampling variability on a constant, static, noisy signal. Using a combination of real and simulated data, we examined the relationship between cofluctuation and network structure and asked if this relationship was unique, or if it could arise from sampling variability alone. First, we show that events are not discrete - there is a gradually increasing relationship between network structure and cofluctuation; ∼50% of samples show very strong network structure. Second, using simulations we show that this relationship is predicted from sampling variability on static FC. Finally, we show that randomly selected points can capture network structure about as well as events, largely because of their temporal spacing. Together, these results suggest that, while events exhibit particularly strong representations of static FC, there is little evidence that events are unique timepoints that drive FC structure. Instead, a parsimonious explanation for the data is that events arise from a single static, but noisy, FC structure.

Indexed as

BrainBrain MappingHumansMagnetic Resonance ImagingNeural PathwaysCofluctuationsEventsNetworksResting-state fMRIRSFCSimulations

Identifiers

PMID35842100
PMCPMC9428936
OpenAlexW4285401153

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.