ReviewThe Lancet. Neurology2022
Diagnosis and treatment of orthostatic hypotension.
Review in The Lancet. Neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07309666 (Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension), which is not on this map. Cited by 125 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Research, Development, and Application of Intelligent Diagnostic System for Orthostatic Hypotension
Who cites it
125 citing papers in PubMed, 5 syntheses or guidelines pooled it, 176 citations in OpenAlex.
- A Review of Clinical Trial and Meta-Analyses of BP Treatment Strategies for Patients with Orthostatic Hypotension: Blood Pressure Management in Patients with Hypertension and Orthostatic Hypotension.Current hypertension reports · 2026Pooled it
- Prevalence of Supine Hypertension in Alpha-Synucleinopathies: A Systematic Review and Meta-Analysis.Movement disorders clinical practice · 2025Pooled it
- Diagnosis and treatment of autonomic failure, pain and sleep disturbances in Parkinson's disease: guideline "Parkinson's disease" of the German Society of Neurology.Journal of neurology · 2025Guideline
- Short term cardiovascular symptoms improvement after deep brain stimulation in patients with Parkinson's disease: a systematic review.Journal of neurology · 2024Pooled it
- Prevalence and incidence of orthostatic hypotension in patients with Parkinson's disease: an updated systematic review and meta-analysis.Frontiers in neurologyPooled it
- Characterization and clinical management of adverse events following treatment with repotrectinib: a TRIDENT-1 analysis.The oncologist · 2026Trial
- Establishing minimally clinically important differences for the orthostatic hypotension questionnaire (OHQ).Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Trial
- Ten tips to reduce fracture risk by non-pharmacologic interventions in CKD-associated osteoporosis.Clinical kidney journal · 2026Review
- Coexisting Postural Orthostatic Tachycardia Syndrome on Autonomic Reflex Testing in Functional Neurologic Disorder.The American journal of case reports · 2026Article
- Management of Syncope in Geriatric Patients: Are 2018 European Society of Cardiology Guidelines Still Relevant?Journal of clinical medicine · 2026Review
- Cardiogenic vertigo: clinical characteristics and predictors of long-term prognosis.Journal of neurology · 2026Article
- Cerebral oxygenation response to postural change using continuous near-infrared spectroscopy (NIRS) and its association with falls in older adults.European geriatric medicine · 2026Article
- Orthostatic blood pressure disorders in older adults: clinical phenotypes, diagnostic challenges, and cognitive and functional implications.Journal of geriatric cardiology : JGC · 2026Article
- Diagnostic accuracy of the COMPASS-31 orthostatic intolerance domain for detecting cardiovascular autonomic neuropathy in resource-limited settings.Cardiovascular diabetology. Endocrinology reports · 2026Article
- Physiological Responses to Prior Verbal Notice Before Passive Postural Change: A Randomized Crossover Exploratory Study of Circulatory and Autonomic Dynamics.Healthcare (Basel, Switzerland) · 2026Article
- Orthostatic Hypotension in Hypertensive Patients Hospitalized in Italian Internal Medicine Departments: FADOI-HYP-OP Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Article
- Exploring the Link Between Pharmacological Management of Orthostatic Hypotension and Cognitive Performance: A Scoping Review.Drugs & aging · 2026Article
- The combined association of STOPPFall medication use and orthostatic blood pressure abnormalities with future falls and fractures in community-dwelling older people.European geriatric medicine · 2026Article
- Clinical, Neuropathic, and Sudomotor Correlates of Orthostatic Hypotension in Type 2 Diabetes: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 7 institutions in 4 countries.
Funding
Abstract
Orthostatic hypotension is an unusually large decrease in blood pressure on standing that increases the risk of adverse outcomes even when asymptomatic. Improvements in haemodynamic profiling with continuous blood pressure measurements have uncovered four major subtypes: initial orthostatic hypotension, delayed blood pressure recovery, classic orthostatic hypotension, and delayed orthostatic hypotension. Clinical presentations are varied and range from cognitive slowing with hypotensive unawareness or unexplained falls to classic presyncope and syncope. Establishing whether symptoms are due to orthostatic hypotension requires careful history taking, a thorough physical examination, and supine and upright blood pressure measurements. Management and prognosis vary according to the underlying cause, with the main distinction being whether orthostatic hypotension is neurogenic or non-neurogenic. Neurogenic orthostatic hypotension might be the earliest clinical manifestation of Parkinson's disease or related synucleinopathies, and often coincides with supine hypertension. The emerging variety of clinical presentations advocates a stepwise, individualised, and primarily non-pharmacological approach to the management of orthostatic hypotension. Such an approach could include the cessation of blood pressure lowering drugs, adoption of lifestyle measures (eg, counterpressure manoeuvres), and treatment with pharmacological agents in selected cases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.