ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2022
Identifying transcranial magnetic stimulation induced EEG signatures of different neuronal elements in primary motor cortex.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.
- Methodological Choices Matter: A Systematic Comparison of TMS-EEG Studies Targeting the Primary Motor Cortex.Human brain mapping · 2024Pooled it
- Investigating the effects of TMS-related somatosensory inputs on TMS-evoked potentials provides evidence against significant interaction.Scientific reports · 2026Article
- Long-interval intracortical inhibition is similar in people with and without amyotrophic lateral sclerosis.Brain communications · 2026Article
- Motor Cortical Correlates of Paired Associative Stimulation Induced Plasticity: A TMS-EEG Study.Brain sciences · 2023Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
Abstract
objectiveTo investigate the neuronal elements involved in the activation of corticospinal neurons in the primary motor cortex (M1).
methodsWe studied 10 healthy subjects. Cortical evoked potentials with different components induced by monophasic transcranial magnetic stimulation (TMS) in anterior-posterior and posterior-anterior currents recorded with electroencephalography (EEG) were analyzed.
resultsEEG signatures with P25 and N45 components recorded at the C3 electrode with posterior-anterior current were larger than those with anterior-posterior current, while the signatures with P180 and N280 components recorded at the FC1 electrode with anterior-posterior current were larger than those with posterior-anterior current. The source localization analysis revealed that the cortical evoked potential with anterior-posterior current distributed both in the M1 and premotor cortex while that with posterior-anterior current only located in the M1.
conclusionsWe conclude that the activation of corticospinal pyramidal neurons in the M1 is affected by various neuronal elements including the local intracortical circuits in the M1 and inputs from premotor cortex with different sensitivities to TMS in opposite current directions. SIGNIFICANCE: Our finding helped answer a longstanding question about how the corticospinal pathway from the M1 is functionally organized and activated.
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Registered trials
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