Evidence map›Paper›PMID 35841603›Full record

ArticleEvolution; international journal of organic evolution2022

Secondary reversion to sexual monomorphism associated with tissue-specific loss of doublesex expression.

Jian-Jun Gao, Olga Barmina, Ammon Thompson, Bernard Y Kim, Anton Suvorov, Kohtaro Tanaka, Hideaki Watabe, Masanori J Toda, Ji-Min Chen, Takehiro K Katoh and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evolution; international journal of organic evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Morphological innovation without gene co-option: thebioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Jian-Jun GaoYunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology, Yunnan University, China.ORCID 0000-0003-4636-2130
Olga BarminaDepartment of Evolution and Ecology, University of California Davis, Davis, CA, 95616, USA.
Ammon ThompsonDepartment of Evolution and Ecology, University of California Davis, Davis, CA, 95616, USA.
Bernard Y KimDepartment of Biology, Stanford University, Stanford, CA, 94305, USA.
Anton SuvorovDepartment of Genetics, University of North Carolina, Chapel Hill, NC, 27599, USA.ORCID 0000-0003-3898-9195
Kohtaro TanakaDepartment of Evolution and Ecology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0001-5137-3534
Hideaki WatabeThe Hokkaido University Museum, Kita-10, Nishi-8, Kitaku, Sapporo, 060-0810, Japan.
Masanori J TodaThe Hokkaido University Museum, Kita-10, Nishi-8, Kitaku, Sapporo, 060-0810, Japan.ORCID 0000-0003-0158-1858
Ji-Min ChenState Key Laboratory for Conservation and Utilization of Bioresources in Yunnan, Yunnan University, China.
Takehiro K KatohYunnan Key Laboratory of Plant Reproductive Adaptation and Evolutionary Ecology, Yunnan University, China.
Artyom KoppDepartment of Evolution and Ecology, University of California Davis, Davis, CA, 95616, USA.ORCID 0000-0001-5224-0741
University of California, Davis · USYunnan University · CNHokkaido University · JPStanford University · USUniversity of North Carolina at Chapel Hill · US

Funding

Molecular Genetics of Evolutionary InnovationsR35GM122592 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI ARTYOM KOPP · 2017 to 2026
$4.5M
LEICA AOBS SP2 CONFOCAL FOR THE MCB/DBS IMAGING FACILITY: CELL BIOLOGYS10RR019266 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI NUNNARI, JODI M · 2004 to 2004
$496k
A comparative population genomic approach for high-resolution inference of natural selection in fruit fliesF32GM135998 · NIGMS · STANFORD UNIVERSITY · PI KIM, BERNARD YOUNGSOO · 2020 to 2021
$131k
NCRR NIH HHS S10 RR019266NIGMS NIH HHS F32 GM135998NIGMS NIH HHS R35 GM122592
6 · The paper itself

Abstract

Animal evolution is characterized by frequent turnover of sexually dimorphic traits-new sex-specific characters are gained, and some ancestral sex-specific characters are lost, in many lineages. In insects, sexual differentiation is predominantly cell autonomous and depends on the expression of the doublesex (dsx) transcription factor. In most cases, cells that transcribe dsx have the potential to undergo sex-specific differentiation, while those that lack dsx expression do not. Consistent with this mode of development, comparative research has shown that the origin of new sex-specific traits can be associated with the origin of new spatial domains of dsx expression. In this report, we examine the opposite situation-a secondary loss of the sex comb, a male-specific grasping structure that develops on the front legs of some drosophilid species. We show that while the origin of the sex comb is linked to an evolutionary gain of dsx expression in the leg, sex comb loss in a newly identified species of Lordiphosa (Drosophilidae) is associated with a secondary loss of dsx expression. We discuss how the developmental control of sexual dimorphism affects the mechanisms by which sex-specific traits can evolve.

Indexed as

Drosophila ProteinsAnimalsDNA-Binding ProteinsDrosophila melanogasterFemaleGene Expression Regulation, DevelopmentalMaleSex CharacteristicsSex DifferentiationDNA-Binding ProteinsDrosophila ProteinsDSX protein, DrosophiladoublesexDrosophilaevolutionLordiphosamale-specific structuressex combssexual dimorphismtrait loss

Identifiers

PMID35841603
PMCPMC10348355
OpenAlexW4285588369

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.