ArticleBrain imaging and behavior2022
Semantic fluency deficits and associated brain activity in Parkinson's disease with mild cognitive impairment.
Article in Brain imaging and behavior, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 19 citations in OpenAlex.
- Evaluating the clinical effects of GLP-1 receptor agonists for Alzheimer's and Parkinson's diseases using minimal clinically important difference: systematic review and meta-analysis.Archives of pharmacal research · 2026Pooled it
- Task-based fMRI brain activation in mild cognitive impairment and Alzheimer's disease: an ALE meta-analysis.GeroScience · 2026Pooled it
- A cross-sectional and longitudinal study of changes in complex networks related to brain function in temporal lobe epilepsy patients treated with levetiracetam intervention therapy.Brain imaging and behavior · 2026Article
- Early Autonomic Burden in Prodromal Parkinson's Disease Predicts Cognitive Impairment.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Language skills in Parkinson's disease: state of the art.Dementia & neuropsychologia · 2026Review
- Subitem-level multi-scale assessment and machine learning for three-class cognitive status classification in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Cognitive Phenotyping of Parkinson's Disease Patients Via Digital Analysis of Spoken Word Properties.Movement disorders : official journal of the Movement Disorder Society · 2025Article
- Cortical activation and functional connectivity between healthy elderly and Parkinson's disease patients and between cognitive subgroups of Parkinson's patients: a multichannel functional near-infrared spectroscopy study.Frontiers in aging neuroscience · 2025Article
- The role ofFrontiers in neuroscience · 2025Review
- Cognitive reorganization in patients with Parkinson's Disease and Mild Cognitive Impairment: a neuropsychological network approach.Scientific reports · 2024Article
- Psychometrics and diagnostics of the Italian version of the Alternate Verbal Fluency Battery (AVFB) in non-demented Parkinson's disease patients.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Change in Neurocognitive Function in Patients Who Receive CAR-T Cell Therapies: A Steep Hill to Climb.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Hippocampal resting-state connectivity is associated with posterior-cortical cognitive impairment in Parkinson's disease.Brain and behavior · 2024Article
- Assessment tools for cognitive performance in Parkinson's disease and its genetic contributors.Frontiers in neurology · 2024Article
- Clustering and Switching in Semantic Verbal Fluency: Their Development and Relationship with Word Productivity in Typically Developing Greek-Speaking Children and Adolescents.Journal of Intelligence · 2023Article
- Smaller and Denser Speech Graphs in Nondemented Patients with Progressive Supranuclear Palsy.Behavioural neurology · 2023Article
- Regression-Based Normative Data for Independent and Cognitively Active Spanish Older Adults: Verbal Fluency Tests and Boston Naming Test.International journal of environmental research and public health · 2022Article
- The effect of levodopa on speech graphs in non-demented patients with multiple system atrophy and Parkinson's disease.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
People living with Parkinson's disease (PD) with poor verbal fluency have an increased risk of developing dementia. This study examines the neural mechanisms underpinning semantic fluency deficits in patients with PD with mild cognitive impairment (PD-MCI) compared to those without MCI (PD-NC) and control participants without PD (non-PD). Thirty-seven (37) participants with PD completed a cognitive assessment battery to identify MCI (13 PD-MCI). Twenty sex- and age-matched non-PD patients also participated. Participants were scanned (3T Siemens PRISMA) while performing semantic fluency, semantic switching, and automatic speech tasks. The number of responses and fMRI data for semantic generation and semantic switching were analyzed. Participants also completed a series of verbal fluency tests outside the scanner, including letter fluency. Participants with PD-MCI performed significantly worse than PD-NC and non-PD participants during semantic fluency and semantic switching tasks. PD-MCI patients showed greater activity in the right angular gyrus than PD-NC and non-PD patients during semantic switching. Increased right angular activity correlated with worse verbal fluency performance outside the scanner. Our study showed that the PD-MCI group performed worse on semantic fluency than either the PD-NC or non-PD groups. Increased right angular gyrus activity in participants with PD-MCI during semantic switching suggests early compensatory mechanisms, predicting the risk of future dementia in PD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.