ArticleCancer medicine2023
Association of serum Klotho levels with cancer and cancer mortality: Evidence from National Health and Nutrition Examination Survey.
Article in Cancer medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 36 citations in OpenAlex.
- Association of serum Klotho and fibroblast growth factor-23 levels with vascular calcification severity in patients with chronic kidney disease: an observational cohort study.International urology and nephrology · 2025Observational
- Observational
- Partial renal deletion of Klotho is not sufficient to impact renal electrolyte handling in distal convoluted tubule specific knock-out mice.Physiological reports · 2025Article
- Klotho antiaging protein: molecular mechanisms and therapeutic potential in diseases.Molecular biomedicine · 2025Review
- Systemic immune-inflammation index mediates the association between abdominal obesity and serum klotho levels.Scientific reports · 2025Article
- Association ofInternational journal of molecular sciences · 2025Article
- Unveiling the Emerging Role of Klotho: A Comprehensive Narrative Review of an Anti-aging Factor in Human Fertility.Current protein & peptide science · 2025Review
- The relationship between serum α-Klotho with all-cause and cause-specific mortality.British journal of clinical pharmacology · 2024Article
- The associations between oxidative balance score and serum Klotho level in the U.S. population aged 40-79 years.Scientific reports · 2024Article
- Gender-specific association between circulating serum Klotho and metabolic components in adults.BMC endocrine disorders · 2024Article
- Sexually dimorphic renal expression of mouse Klotho is directed by a kidney-specific distal enhancer responsive to HNF1b.Communications biology · 2024Article
- Article
- Sexually dimorphic renal expression ofResearch square · 2024Article
- Serum klotho levels and mortality patterns in frail individuals: unraveling the u-shaped association.Aging clinical and experimental research · 2024Article
- Association of prognostic nutritional index with mortalities in American adult cancer survivors: A cohort study based on NHANES, 1999-2018.Food science & nutrition · 2024Article
- U-shaped association between serum Klotho and all-cause mortality in US cardiovascular patients: a prospective cohort study.Frontiers in endocrinology · 2024Article
- Association of serum klotho with cognitive function among individuals with nonalcoholic fatty liver disease.Frontiers in aging neuroscience · 2024Article
- Association between cigarette smoking and serum alpha klotho levels among US adults over 40-years-old: a cross-sectional study.Scientific reports · 2023Article
- [Research Progress of Klotho in Lung Neoplasms].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2023Article
- Association between Serum Soluble α-Klotho and Urinary Albumin Excretion in Middle-Aged and Older US Adults: NHANES 2007-2016.Journal of clinical medicine · 2023Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKlotho has both anticancer and hormone-like functions. But the research on Klotho and cancer is mainly based on animal experiments and small-scale clinical research, thus we explored the association between serum Klotho and cancer and cancer mortality based on the National Health and Nutrition Survey (NHANES).
methodsParticipants were employed from the NHANES 2007-2016, excluding pregnant, chronic renal insufficiency, and incomplete data of cancer questionnaire and serum Klotho level. The association of serum Klotho with cancer and mortality was analyzed by weighted Logistic regression, weighted Cox regression and competitive risk model, respectively. Correlations between serum Klotho and testosterone and estradiol levels were analyzed by Spearman correlation and restricted cubic spline respectively.
resultsWe found Klotho had an inverse effect with risk of pan-cancer (all p < 0.02), with each unit increase in Klotho (1ug/g creatinine) associated with a 0.9%-2.2% reduction in the risk of cancer, and higher levels showing a stronger negative association (all p-trend <= 0.0005). Whereas, we did not observe any association between serum Klotho level with all-cause mortality and cancer-specific mortality (all p > 0.05). Then, stratified analysis found that people aged 60-79, female, overweight and non-Hispanic whites or Mexican Americans were less likely to develop cancer. In addition, there was a strong nonlinear and linear positive correlation of Klotho with estradiol (p-nonlinear = 0.0178) and testosterone only among male participants (β = -0.513, p = 0.0137), respectively.
conclusionsWe found an inverse association between serum Klotho and cancer, but without cancer mortality. And this effect may be partially mediated by estradiol and testosterone. Further prospective studies are needed to prove these findings.
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