ArticleMovement disorders : official journal of the Movement Disorder Society2022
Dissecting the Domains of Parkinson's Disease: Insights from Longitudinal Item Response Theory Modeling.
Article in Movement disorders : official journal of the Movement Disorder Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 16 citations in OpenAlex.
- Longitudinal Evaluation of an Abbreviated Patient-Reported Movement Disorder Society-sponsored revision of the Unified Parkinson's Disease Rating Scale (MDS-UPDRS) for Predicting Dopaminergic Therapy Initiation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Optimizing Parkinson's disease progression scales using computational methods.NPJ Parkinson's disease · 2026Article
- Timing of device-aided therapy initiation in Parkinson's disease: reference estimates for healthcare planning and biological heterogeneity.Clinical parkinsonism & related disorders · 2026Article
- Optimizing the MDS-UPDRS Part III for early-stage Parkinson's: early supportive evidence for a limb-related bradykinesia/rigidity sub-score.NPJ Parkinson's disease · 2025Article
- Tremor is Commonly Responsive to Levodopa Along the Natural History of Parkinson's Disease.Movement disorders clinical practice · 2025Article
- Personalized progression modelling and prediction in Parkinson's disease with a novel multi-modal graph approach.NPJ Parkinson's disease · 2024Article
- Tips and tricks in tremor treatment.Journal of neural transmission (Vienna, Austria : 1996) · 2024Review
- Patient-centered development of clinical outcome assessments in early Parkinson disease: key priorities and advances.NPJ Parkinson's disease · 2024Article
- Co-Existent Probable RBD and PD: Disease Progression, Medication Response, and Clinical Trial Implications.Movement disorders clinical practice · 2024Article
- Role of dopamine agonists in Parkinson's disease therapy.Journal of neural transmission (Vienna, Austria : 1996) · 2023Review
- Using Movement Disorder Society Unified Parkinson's Disease Rating Scale Parts 2 and 3 Simultaneously: Combining the Patient Voice with Clinician Ratings.Movement disorders : official journal of the Movement Disorder Society · 2023Article
- Movement Disorder Society Unified Parkinson's Disease Rating Scale Motor Examination Retains Its 2-Domain Profile in BothMovement disorders clinical practice · 2022Article
- Assessing tilavonemab efficacy in early Alzheimer's disease via longitudinal item response theory modeling.Alzheimer's & dementia (New York, N. Y.)Article
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
Abstract
backgroundLongitudinal item response theory (IRT) models previously suggested that the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) motor examination has two salient domains, tremor and nontremor, that progress in time and in response to treatment differently.
objectiveApply longitudinal IRT modeling, separating tremor and nontremor domains, to reanalyze outcomes in the previously published clinical trial (Study of Urate Elevation in Parkinson's Disease, Phase 3) that showed no overall treatment effects.
methodsWe applied unidimensional and multidimensional longitudinal IRT models to MDS-UPDRS motor examination items in 298 participants with Parkinson's disease from the Study of Urate Elevation in Parkinson's Disease, Phase 3 (placebo vs. inosine) study. We separated 10 tremor items from 23 nontremor items and used Bayesian inference to estimate progression rates and sensitivity to treatment in overall motor severity and tremor and nontremor domains.
resultsThe progression rate was faster in the tremor domain than the nontremor domain before levodopa treatment. Inosine treatment had no effect on either domain relative to placebo. Levodopa treatment was associated with greater slowing of progression in the tremor domain than the nontremor domain regardless of inosine exposure. Linear patterns of progression were observed. Despite different domain-specific progression patterns, tremor and nontremor severities at baseline and over time were significantly correlated.
conclusionsLongitudinal IRT analysis is a novel statistical method addressing limitations of traditional linear regression approaches. It is particularly useful because it can simultaneously monitor changes in different, but related, domains over time and in response to treatment interventions. We suggest that in neurological diseases with distinct impairment domains, clinical or anatomical, this application may identify patterns of change unappreciated by standard statistical methods. © 2022 International Parkinson and Movement Disorder Society.
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