ArticleRadiation oncology (London, England)2022
Organ-at-risk sparing with dynamic trajectory radiotherapy for head and neck cancer: comparison with volumetric arc therapy on a publicly available library of cases.
Article in Radiation oncology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 17 citations in OpenAlex.
- Robustness assessment of radiotherapy treatment plans in Switzerland.Zeitschrift fur medizinische Physik · 2026Article
- Simultaneous optimization of multiple plans within one treatment course with dosimetric pathfinding for temporally feathered radiation therapy.Medical physics · 2025Article
- Dosimetric and robustness evaluation of biaxially rotational dynamic radiation therapy with robust optimization.Journal of applied clinical medical physics · 2025Article
- A randomized safety study of tolerance to table rotation in dynamic trajectory radiotherapy in healthy volunteers.Physics and imaging in radiation oncology · 2025Article
- Dosimetric optimization for dynamic mixed beam arc therapy (DYMBARC).Medical physics · 2025Article
- Determination of patient-specific trajectory for biaxially rotational dynamic-radiation therapy using a new O-ring-shaped image guided radiotherapy system.Physics and imaging in radiation oncology · 2025Article
- Robustness analysis of dynamic trajectory radiotherapy and volumetric modulated arc therapy plans for head and neck cancer.Physics and imaging in radiation oncology · 2024Article
- Dosimetric Comparison of Coplanar, Non-coplanar, and Mixed-Arc VMAT for Head and Face Skin Cancers: A Multi-scenario Analysis.Cancer diagnosis & prognosisArticle
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDynamic trajectory radiotherapy (DTRT) extends volumetric modulated arc therapy (VMAT) with dynamic table and collimator rotation during beam-on. The aim of the study is to establish DTRT path-finding strategies, demonstrate deliverability and dosimetric accuracy and compare DTRT to state-of-the-art VMAT for common head and neck (HN) cancer cases.
methodsA publicly available library of seven HN cases was created on an anthropomorphic phantom with all relevant organs-at-risk (OARs) delineated. DTRT plans were generated with beam incidences minimizing fractional target/OAR volume overlap and compared to VMAT. Deliverability and dosimetric validation was carried out on the phantom.
resultsDTRT and VMAT had similar target coverage. For three locoregionally advanced oropharyngeal carcinomas and one adenoid cystic carcinoma, mean dose to the contralateral salivary glands, pharynx and oral cavity was reduced by 2.5, 1.7 and 3.1 Gy respectively on average with DTRT compared to VMAT. For a locally recurrent nasopharyngeal carcinoma, D
conclusionsThis study provides a proof of principle of DTRT for common HN cases with plans that were deliverable on a C-arm linac with high accuracy. The comparison with VMAT indicates substantial OAR sparing could be achieved.
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