Evidence map›Paper›PMID 35840949›Full record

Trial reportBMC public health2022

Investigating feasibility of 2021 WHO protocol for cervical cancer screening in underscreened populations: PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC).

Marat Sultanov, Janine de Zeeuw, Jaap Koot, Jurjen van der Schans, Jogchum J Beltman, Marlieke de Fouw, Marek Majdan, Martin Rusnak, Naheed Nazrul, Aminur Rahman and 8 more

2 registry-linked trialsOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMC public health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05234112 nacompletednot on this map

Prevention and Screening Intervention Project - Towards Elimination of Cervical Cancer

TypeinterventionalSponsorUniversity Medical Center GroningenRan2022 to 2024Enrolled30,000ConditionsHPV Infection, Cervix Cancer, Cervical DysplasiaArmsCommunity mobilisation for hrHPV self-testing, hrHPV self-testing, Follow-up after testing, VIA, Thermo-ablation or cryotherapy for dysplasia
NCT06452004 naunknown statusnot on this map

Prevention and Screening Intervention Project - Towards Elimination of Cervical Cancer: Validation of Artificial Intelligence as Decision Support System in VIA

TypeinterventionalSponsorUniversity Medical Center GroningenRan2022 to 2025Enrolled600ConditionsHPV Infection, Cervix Cancer, Cervical DysplasiaArmsValidation of AI-DSS in Bangladesh, Validation of AI-DSS in Uganda, Validation of AI-DSS in India
3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 23 citations in OpenAlex.

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  19. Artificial intelligence and visual inspection in cervical cancer screening.International journal of gynecological cancer : official journal of the International Gynecological Cancer Society · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 6 institutions in 5 countries.

Marat SultanovDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands. m.sultanov@umcg.nl.ORCID 0000-0002-5746-811X
Janine de ZeeuwDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jaap KootDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jurjen van der SchansDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jogchum J BeltmanDepartment of Gynecology, Leiden University Medical Centre, Leiden University, Leiden, Netherlands.
Marlieke de FouwDepartment of Gynecology, Leiden University Medical Centre, Leiden University, Leiden, Netherlands.
Marek MajdanInstitute for Global Health and Epidemiology, Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovak Republic.
Martin RusnakInstitute for Global Health and Epidemiology, Department of Public Health, Faculty of Health Sciences and Social Work, Trnava University, Trnava, Slovak Republic.
Naheed NazrulFriendship Foundation, Dhaka, Bangladesh.
Aminur RahmanHealth System and Population Studies Division, icddr,b, Dhaka, Bangladesh.
Carolyn NakisigeUganda Cancer Institute, Kampala, Uganda.
Arathi P RaoPrasanna School of Public Health, Manipal Academy of Higher Education, Manipal, India.
Keerthana PrasadManipal School of Information Sciences, Manipal Academy of Higher Education, Manipal, India.
Shyamala GuruvareKasturba Medical College, Manipal Academy of Higher Education, Manipal, India.
Regien BiesmaDepartment of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Marco VersluisDepartment of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Geertruida H de Bock *Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
Jelle Stekelenburg *Department of Health Sciences, Global Health Unit, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.
University Medical Center Groningen · NLManipal Academy of Higher Education · INLeiden University · NLUniversity of Trnava · SKInternational Centre for Diarrhoeal Disease Research · BDUganda Cancer Institute · UG

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
FIC NIH HHS D43 TW010540
6 · The paper itself

Abstract

backgroundHigh-risk human papillomavirus (hrHPV) testing has been recommended by the World Health Organization as the primary screening test in cervical screening programs. The option of self-sampling for this screening method can potentially increase women's participation. Designing screening programs to implement this method among underscreened populations will require contextualized evidence.

methodsPREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC) will use a multi-method approach to investigate the feasibility of implementing a cervical cancer screening strategy with hrHPV self-testing as the primary screening test in Bangladesh, India, Slovak Republic and Uganda. The primary outcomes of study include uptake and coverage of the screening program and adherence to follow-up. These outcomes will be evaluated through a pre-post quasi-experimental study design. Secondary objectives of the study include the analysis of client-related factors and health system factors related to cervical cancer screening, a validation study of an artificial intelligence decision support system and an economic evaluation of the screening strategy. DISCUSSION: PRESCRIP-TEC aims to provide evidence regarding hrHPV self-testing and the World Health Organization's recommendations for cervical cancer screening in a variety of settings, targeting vulnerable groups. The main quantitative findings of the project related to the impact on uptake and coverage of screening will be complemented by qualitative analyses of various determinants of successful implementation of screening. The study will also provide decision-makers with insights into economic aspects of implementing hrHPV self-testing, as well as evaluate the feasibility of using artificial intelligence for task-shifting in visual inspection with acetic acid.

trial registrationClinicalTrials.gov, NCT05234112 . Registered 10 February 2022.

Indexed as

Papillomavirus InfectionsUterine Cervical NeoplasmsArtificial IntelligenceEarly Detection of CancerFeasibility StudiesFemaleHumansMass ScreeningPapillomaviridaeWorld Health OrganizationBangladeshCervical cancerCervical cancer screeningHuman papillomavirus testingImplementationIndiaSlovakiaUganda

Identifiers

PMID35840949
PMCPMC9284962
OpenAlexW4285492447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.