ArticleThe journal of headache and pain2022
Interictal osmophobia is associated with longer migraine disease duration.
Article in The journal of headache and pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Olfactory abnormalities in patients with migraine: a narrative review of a symptom commonly overlooked by neurologists.Journal of oral & facial pain and headache · 2025Review
- Osmophobia in Patients With Migraine: A Systematic Review and Meta-Analysis.World journal of otorhinolaryngology - head and neck surgery · 2025Review
- Validation of an 8-item self-administered questionnaire for assessing migraine-related sensory hypersensitivities (MHQ-8).The journal of headache and pain · 2025Article
- Association of the insulin resistance marker triglyceride glucose index with migraine: results of a cross-sectional and prospective cohort study.Journal of oral & facial pain and headache · 2025Article
- Relationship between food triggers and sensory hypersensitivity in patients with migraine.Arquivos de neuro-psiquiatria · 2024Article
- Aura and osmophobia are associated with the IL1A -889C > T (rs1800587) variant in migraine.Arquivos de neuro-psiquiatria · 2024Article
- Evaluating the Frequency of Osmophobia in Tension-Type Headache: A Comparative Study on Migraine.Cureus · 2024Article
- Children and adolescents with primary headaches exhibit altered sensory profiles - a multi-modal investigation.The journal of headache and pain · 2024Article
- Beyond Pain: The Effects of OnabotulinumtoxinA Therapy on Sensitization and Interictal Symptoms in Chronic Migraine.Toxins · 2024Review
- [Complementary and supplementary procedures in the treatment of headache].Schmerz (Berlin, Germany) · 2023Review
- Article
- Migraine Disability Improvement during Treatment with Galcanezumab in Patients with Chronic and High Frequency Episodic Migraine.Neurology international · 2023Article
- The not so hidden impact of interictal burden in migraine: A narrative review.Frontiers in neurology · 2022Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSensitization to sensory stimuli is an essential feature of migraine attacks. The relationship between the clinical course of migraine and increased sensitivity to olfactory stimuli has been little studied so far.
methodsWe analyzed the frequency and quality of osmophobia depending on the phase of migraine in patients with episodic and chronic migraine treated in an tertiary headache center with regard to gender, age, medical history and migraine disability assessment score (MIDAS). Standardized diagnostic questions were used for the assessment of osmophobia.
resultsIn our cross-sectional investigation (n = 113), 38.1% of the patients showed an increased preictal hypersensitivity to odors, whereas 61.9% described ictal and 31.9% interictal hypersensitivity to odors, odor-triggered migraine was described in 30.1%. Median migraine disease duration has been statistically significantly longer in patients who suffered from interictal hypersensitivity to odors (28.5 years vs. 20 years; p = 0.012). There was a significant correlation between interictal hypersensitivity and higher age (54.50 vs. 45; p = 0.015). Patients with higher migraine disability in MIDAS experienced more frequently preictal and interictal olfactory sensitization and odor triggered migraine attacks.
conclusionsIn patients with longer migraine disease duration and higher migraine-related impairment, osmophobia was more frequently observed. These results might support the hypothesis of increasing sensitization with increasing burden of migraine.
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