ArticleMolecular psychiatry2022
Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders.
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 4 of them syntheses that pooled it.
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Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- Revisiting the link between childhood adversity and stress-sensitive brain regions in psychosis and bipolar disorder: a systematic review and meta-analysis.Translational psychiatry · 2026Pooled it
- Transdiagnostic mapping of brain structural abnormalities and network-constrained gray matter atrophy patterns across affective and psychotic disorders.Molecular psychiatry · 2026Pooled it
- DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.EBioMedicine · 2026Pooled it
- The neuroanatomy of depression: weak but replicable effects in 4021 individuals from three clinical cohorts.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The role of social support in transdiagnostic symptom networks in affective and psychotic disorders: a cross-sectional and longitudinal network analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Neurostimulation in the treatment of psychiatric disorders: Underlying mechanisms and critical analysis of circuit-based interventions.Molecular psychiatry · 2026Review
- Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity.Brain structure & function · 2026Article
- The Toll-Like Receptor Signalling Pathway Is Altered in iPSC-Derived Cortical Networks From People With Bipolar Disorder.Bipolar disorders · 2026Article
- Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders.Molecular psychiatry · 2026Article
- Associations of Midlife Vascular Risk Factors With Late-Life Depressive Symptoms: Findings From the ARIC Study.Journal of the American Heart Association · 2026Article
- Shared Genetic Networks in Schizophrenia and Bipolar Disorder: Hippocampal Volume-Mediated Neurobiological Mechanisms.Schizophrenia bulletin · 2026Article
- Social withdrawal and hippocampal volume among adolescents at clinical high risk for psychosis and healthy comparisons: The moderating role of neighborhood residential stability.Schizophrenia research · 2026Article
- Thalamic nuclei volumes across psychiatric and neurological disorders: a multi-site magnetic resonance imaging study.Translational psychiatry · 2026Article
- Unraveling spatiotemporal dynamics in transdiagnosis subtypes of major depressive disorder and bipolar disorder: insights from co-activation patterns and treatment response.Molecular psychiatry · 2026Article
- The SFB/TRR 393 Collaborative Research Centre: trajectories of affective disorders : Cognitive-emotional mechanisms of symptom change.Der Nervenarzt · 2026Review
- Evaluation of Short Term and Long Term Subjective and Objective Cognitive Outcomes Following ECT for Depression in a Naturalistic Ambulatory Setting: A Cohort Study.Alpha psychiatry · 2026Article
- Differential impact of manic versus depressive episode recurrence on longitudinal gray matter volume changes in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Emotional and cognitive effects of menopause and hormone replacement therapy.Psychological medicine · 2026Article
- Transdiagnostic prevention in youth mental health, Part I: rationale, shared risk factors.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
Corrections and comments
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Authors and funding
21 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk factors, genetics, and other biological measures. Based on previous findings, it remains unclear what transdiagnostic regional gray matter volume (GMV) alterations exist across these disorders, and with which factors they are associated. GMV (3-T magnetic resonance imaging) was compared between healthy controls (HC; n = 110), DSM-IV-TR diagnosed MDD (n = 110), BD (n = 110), and SSD patients (n = 110), matched for age and sex. We applied a conjunction analysis to identify shared GMV alterations across the disorders. To identify potential origins of identified GMV clusters, we associated them with early and current risk and protective factors, psychopathology, and neuropsychology, applying multiple regression models. Common to all diagnoses (vs. HC), we identified GMV reductions in the left hippocampus. This cluster was associated with the neuropsychology factor working memory/executive functioning, stressful life events, and with global assessment of functioning. Differential effects between groups were present in the left and right frontal operculae and left insula, with volume variances across groups highly overlapping. Our study is the first with a large, matched, transdiagnostic sample to yield shared GMV alterations in the left hippocampus across major mental disorders. The hippocampus is a major network hub, orchestrating a range of mental functions. Our findings underscore the need for a novel stratification of mental disorders, other than categorical diagnoses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.