Evidence map›Paper›PMID 35840697›Full record

ArticleScientific reports2022

Impairing proliferation of glioblastoma multiforme with CD44+ selective conjugated polymer nanoparticles.

Dorota Lubanska, Sami Alrashed, Gage T Mason, Fatima Nadeem, Angela Awada, Mitchell DiPasquale, Alexandra Sorge, Aleena Malik, Monika Kojic, Mohamed A R Soliman and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Glioblastoma research on zebrafish xenograft models: a systematic review.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024
    Pooled it
  2. Advancements in Drug Delivery Systems in Glioblastoma Therapy.International journal of molecular sciences · 2026
    Review
  3. Review
  4. Advanced drug delivery platforms target cancer stem cells.Asian journal of pharmaceutical sciences · 2025
    Review
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 3 countries.

Dorota Lubanska *Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Sami Alrashed *Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Gage T Mason *Department of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Fatima NadeemDepartment of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Angela AwadaDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Mitchell DiPasqualeDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Alexandra SorgeDepartment of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Aleena MalikDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Monika KojicDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Mohamed A R SolimanDepartment of Neurosurgery, Faculty of Medicine, Cairo University, Cairo, Egypt.
Ana C deCarvalhoDepartment of Neurosurgery, Henry Ford Hospital, Detroit, MI, 48202, USA.
Abdalla ShamisaSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Swati KulkarniSchulich School of Medicine and Dentistry, Western University, London, ON, Canada.
Drew MarquardtDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada.
Lisa A PorterDepartment of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada. lporter@uwindsor.ca.
Simon Rondeau-GagnéDepartment of Chemistry and Biochemistry, University of Windsor, 401 Sunset Ave., Windsor, ON, N9B 3P4, Canada. srondeau@uwindsor.ca.
University of Windsor · CAWestern University · CAHenry Ford Hospital · USUniversity at Buffalo, State University of New York · US

Funding

CIHR 406811
6 · The paper itself

Abstract

Glioblastoma is one of the most aggressive types of cancer with success of therapy being hampered by the existence of treatment resistant populations of stem-like Tumour Initiating Cells (TICs) and poor blood-brain barrier drug penetration. Therapies capable of effectively targeting the TIC population are in high demand. Here, we synthesize spherical diketopyrrolopyrrole-based Conjugated Polymer Nanoparticles (CPNs) with an average diameter of 109 nm. CPNs were designed to include fluorescein-conjugated Hyaluronic Acid (HA), a ligand for the CD44 receptor present on one population of TICs. We demonstrate blood-brain barrier permeability of this system and concentration and cell cycle phase-dependent selective uptake of HA-CPNs in CD44 positive GBM-patient derived cultures. Interestingly, we found that uptake alone regulated the levels and signaling activity of the CD44 receptor, decreasing stemness, invasive properties and proliferation of the CD44-TIC populations in vitro and in a patient-derived xenograft zebrafish model. This work proposes a novel, CPN- based, and surface moiety-driven selective way of targeting of TIC populations in brain cancer.

Indexed as

GlioblastomaNanoparticlesAnimalsCell Line, TumorCell ProliferationHumansHyaluronan ReceptorsHyaluronic AcidPolymersZebrafishCD44 protein, humanHyaluronan ReceptorsHyaluronic AcidPolymers

Identifiers

PMID35840697
PMCPMC9287456
OpenAlexW4285591215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.