ArticleScientific reports2022
Relaxation anisotropy of quantitative MRI parameters in biological tissues.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 15 citations in OpenAlex.
- First in-vivo magic angle directional imaging using dedicated low-field MRI.Magnetic resonance in medicine · 2025Article
- Anisotropic longitudinal water proton relaxation in white matter investigated ex vivo in porcine spinal cord with sample rotation.Scientific reports · 2024Article
- Quantum dipole interactions and transient hydrogen bond orientation order in cells, cellular membranes and myelin sheath: Implications for MRI signal relaxation, anisotropy, and TMagnetic resonance in medicine · 2024Article
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- Cardiovascular magnetic resonance imaging for sequential assessment of cardiac fibrosis in mice: technical advancements and reverse translation.American journal of physiology. Heart and circulatory physiology · 2024Review
- Dynamic fluctuations in brain iron content during migraine attacks: insights from relaxometry and diffusion tensor imaging.Frontiers in neurology · 2024Article
- Fast Compressed Sensing of 3D Radial TJournal of imaging · 2023Article
- SPICY: a method for single scan rotating frame relaxometry.Physical chemistry chemical physics : PCCP · 2023Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Quantitative MR relaxation parameters vary in the sensitivity to the orientation of the tissue in the magnetic field. In this study, the orientation dependence of multiple relaxation parameters was assessed in various tissues. Ex vivo samples of each tissue type were prepared either from bovine knee (tendon, cartilage) or mouse (brain, spinal cord, heart, kidney), and imaged at 9.4 T MRI with T1, T2, continuous wave (CW-) T1ρ, adiabatic T1ρ and T2ρ, and Relaxation along fictitious field (RAFF2-4) sequences at five different orientations with respect to the main magnetic field. Relaxation anisotropy of the measured parameters was quantified and compared. The highly ordered collagenous tissues, i.e. cartilage and tendon, presented the highest relaxation anisotropy for T2, CW-T1ρ with spin-lock power < 1 kHz, Ad-T2ρ and RAFF2-4. Maximally anisotropy was 75% in cartilage and 30% in tendon. T1 and adiabatic T1ρ did not exhibit observable anisotropy. In the other measured tissue types, anisotropy was overall less than 10% for all the parameters. The results confirm that highly ordered collagenous tissues have properties that induce very clearly observable relaxation anisotropy, whereas in other tissues the effect is not as prominent. Quantitative comparison of anisotropy of different relaxation parameters highlights the importance of sequence choice and design in MR imaging.
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