ArticleInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2022
Short and long-term immune changes in different severity groups of COVID-19 disease.
Article in International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Time-varying mortality risk after gastrointestinal surgery complicated by postoperative infections: a Danish Nationwide study of 859,766 patients.Langenbeck's archives of surgery · 2025Observational
- Article
- Changes in fatigue symptoms following an exercise-based rehabilitation programme for patients with long COVID.ERJ open research · 2024Article
- Prehospital physiological parameters related illness severity scores can accurately discriminate the severe/critical state in adult patients with COVID-19.Annals of medicine · 2023Article
- Human genetic basis of severe or critical illness in COVID-19.Frontiers in cellular and infection microbiology · 2022Review
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17 authors.
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Abstract
backgroundThere are limited data on short- versus long-term changes in adaptive immune response across different COVID-19 disease severity groups.
methodsA multicenter prospective study of 140 adult patients with COVID-19 (a total of 325 samples) were analyzed for inflammatory markers and lymphocyte subsets at presentation, week 2, and week 24.
resultsInflammatory markers at presentation were higher in the critical/severe than in moderate and mild groups. A predominance of memory B cell response in the mild and moderate group was noted by week 2. In contrast, the immune system in the severe/critical group was dysfunctional, with expansion of exhausted CD8+ T cells and atypical memory B cells. By 24 weeks, there was a possible trend of normalization.
conclusionThere was substantial difference in the degree of inflammation and distribution of different B and T cell subsets in the different disease severity groups. Despite the initial dysfunctional immune response in the severe/critical group, a comparable memory B and CD8+ T cell responses to the mild group was achieved at 24 weeks.
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