Trial reportArchives of physical medicine and rehabilitation2022
Randomization to Treadmill Training Improves Physical and Metabolic Health in Association With Declines in Oxidative Stress in Stroke.
Trial report in Archives of physical medicine and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Optimizing physical fitness in chronic stroke patients: the impact of exercise training modality and dosage on maximal and sub-maximal fitness - a systematic review and meta-analysis.Journal of rehabilitation medicine · 2025Pooled it
- Effectiveness of Treadmill Training Intervention for the Management of Patients With Stroke: A Systematic Review and Meta-Analysis.International journal of nursing practice · 2025Pooled it
- Impact of diverse aerobic exercise plans on glycemic control, lipid levels, and functional activity in stroke patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2024Trial
- Physical function frailty trajectory before and after cardiovascular event among older adults in three multinational cohorts.BMC public health · 2026Article
- Effects of three aerobic exercise protocols on acute glucose response and continuous glucose monitoring trends in patients with type 2 diabetes mellitus and stroke: a randomized controlled trial.BMC sports science, medicine & rehabilitation · 2025Article
- Efficacy of Physical Therapy Rehabilitation in the Cardiovascular Deconditioning of Post-Stroke Survivors: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Effects of Mindfulness and Exercise on Growth Factors, Inflammation, and Stress Markers in Chronic Stroke: The MindFit Project Randomized Clinical Trial.Journal of clinical medicine · 2025Article
- Adherence to exercise rehabilitation programmes in stroke survivors: a scoping review.BMJ open sport & exercise medicine · 2025Article
- Systemic Oxidative Stress in Subacute Stroke Patients Undergoing Rehabilitation Treatment.Antioxidants (Basel, Switzerland) · 2024Article
- Elucidating the role of physical exercises in alleviating stroke-associated homeostatic dysregulation: a systematic review and meta-analysis.BMJ open sport & exercise medicine · 2024Article
- Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveTo investigate the effect of aerobic exercise vs control (stretching/balance) on inflammatory and oxidative stress biomarkers in stroke survivors and whether these changes are associated with improvements in physical and metabolic health.
designRandomized controlled trial.
settingThe general communities of Baltimore, Maryland, and Atlanta, Georgia.
participantsTwo hundred forty-six older (>50 years), chronic (>6 months) survivors of stroke (N=246) with hemiparetic gait were recruited, with 51 completing pre-intervention testing and 39 completing postintervention testing. Participants were required to have completed all conventional physical therapy and be capable of walking 3 minutes on a treadmill (N=246).
interventionParticipants completed 6 months of 2 times/wk stretching or balance (ST; n=19) or 3 times/wk aerobic treadmill rehabilitation (TM; n=20;). MAIN OUTCOME MEASURE(S): Peak oxygen uptake rate (V̇o
resultsPhysical function and metabolic health parameters tended to improve after TM but not ST (ST vs TM: V̇o
conclusionsSix months of TM tends to be associated with increased functional capacity and reduced oxidative stress in chronic stroke survivors. Our findings identify potentially modifiable systemic markers of inflammation and oxidative stress important to stroke rehabilitation and provide potential targets for novel therapeutics in future studies.
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