ArticleClinical nutrition (Edinburgh, Scotland)2022
Associations of serum amino acids with insulin resistance among people with and without overweight or obesity: A prospective study in Japan.
Article in Clinical nutrition (Edinburgh, Scotland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The Role of Aromatic Amino Acids in Polycystic Ovary Syndrome through Patients' Blood Metabolic Profiling: A Systematic Review of the Past Five Years.Journal of proteome research · 2025Pooled it
- The hallmarks of protein and amino acid restriction in aging and longevity.Cell press blue · 2026Article
- Dietary Patterns, Eating Disorder Risk, Emotional Distress, and Amino Acid Intake in Adults Seeking Weight Loss.Nutrients · 2026Article
- Trimethylamine N-Oxide Derived from a High-Protein Diet Induces Insulin Resistance in Pregnant Mice via Gut Microbiota Remodeling.Microorganisms · 2026Article
- Multiomics: the intersection of personalized nutrition in cardiometabolic diseases.Journal of translational medicine · 2026Review
- Dysregulation of Plasma Nonessential Amino Acids in Early-Stage Type 2 Diabetes Mellitus.Journal of nutrition and metabolism · 2026Article
- Effect of Plant-Based Diets on Energy Metabolism and Metabolic Functions.Current nutrition reports · 2025Review
- The role of phenylalanine and tyrosine in longevity: a cohort and Mendelian randomization study.Aging · 2025Article
- The Performance ofFoods (Basel, Switzerland) · 2025Article
- High Protein Diet Contributes to Insulin Resistance in Mice via Shaping Gut Microbiota.Microorganisms · 2025Article
- Hyperglycemia correlated with elevated circulating aminoacylase 1 in patients with pre-diabetes and type 2 diabetes.Journal of diabetes and metabolic disorders · 2025Article
- Maternal obesity, age and infant sex influence the profiles of amino acids, energetic metabolites, sugars, and fatty acids in human milk.European journal of nutrition · 2025Observational
- Article
- The Association Between Dietary Intake of Aromatic Amino Acids and Metabolic Syndrome.Journal of nutrition and metabolism · 2025Article
- Free amino acids accelerate the time-dependent inactivation of rat liver nucleotide pyrophosphatase/phosphodiesterase Enpp3 elicited by EDTA.Amino acids · 2024Article
- Serum branch chain amino acids and aromatic amino acids ratio and metabolic risks in Koreans with normal-weight or obesity: a cross-sectional study.Korean journal of community nutrition · 2024Article
- Association between the triglyceride glucose index and atherosclerotic cardiovascular disease in the general population: analysis of the national health and nutrition examination survey 1999-2004.Frontiers in endocrinology · 2024Article
- Genetic risk score for insulin resistance based on gene variants associated to amino acid metabolism in young adults.PloS one · 2024Article
- Dietary essential amino acids for the treatment of heart failure with reduced ejection fraction.Cardiovascular research · 2023Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsLimited evidence exists regarding the prospective associations between amino acids and insulin resistance. In addition, amino acids have been suggested to promote insulin resistance with the requirement of obesity in animal studies, but the interaction between amino acids and obesity on the development of insulin resistance has not been examined in epidemiological studies. We aimed to investigate the differences in the prospective associations of serum amino acids with insulin resistance among adults with and without overweight or obesity.
methodsFasting serum concentrations of 25 amino acids were quantified in 1131 non-diabetic Japanese workers aged 22-71 years at baseline. The homeostasis model assessment of insulin resistance (HOMA-IR) was estimated at baseline and the 3-year follow-up. Generalized linear models were used to assess the associations between amino acids at baseline and HOMA-IR at follow-up with adjustment for potential confounding factors. A Bonferroni-corrected threshold of p = 0.001 was considered significant for multiple tests.
resultsThe associations for the following amino acids with HOMA-IR at the 3-year follow-up significantly varied by obesity status: isoleucine, valine, tyrosine, alanine, and methionine (all p for interaction <0.05). Higher concentrations of serum isoleucine, valine, tyrosine, and alanine (per 1SD) were significantly associated with higher HOMA-IR levels in overweight/obese participants (multivariable-adjusted β coefficients ranging from 0.09 to 0.12; all p < 0.001), but no association was observed in the underweight/normal-weight participants. The associations for serum methionine were direct among overweight/obese participants, but inverse among underweight/normal-weight participants (all p < 0.001).
conclusionsThis study demonstrated the prospective associations of different individual serum amino acids with insulin resistance, with most pronounced associations being for overweight/obese adults. Our findings support the possibility of heterogeneous effects of individual amino acids, as well as their interplay with obesity in the progression of insulin resistance.
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