Evidence map›Paper›PMID 35839386›Full record

ArticleThe Journal of organic chemistry2022

Iridium-Catalyzed Borylation of 6-Fluoroquinolines: Access to 6-Fluoroquinolones.

Aobha Hickey, Julia Merz, Hamad H Al Mamari, Alexandra Friedrich, Todd B Marder, Gerard P McGlacken

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aobha HickeySchool of Chemistry & Analytical and Biological Chemistry Research Facility, University College Cork, Cork T12 YN60, Ireland.
Julia MerzInstitute for Inorganic Chemistry, and Institute for Sustainable Chemistry & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.
Hamad H Al MamariInstitute for Inorganic Chemistry, and Institute for Sustainable Chemistry & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.
Alexandra FriedrichInstitute for Inorganic Chemistry, and Institute for Sustainable Chemistry & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0002-1411-7336
Todd B MarderInstitute for Inorganic Chemistry, and Institute for Sustainable Chemistry & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, Am Hubland, 97074 Würzburg, Germany.ORCID 0000-0002-9990-0169
Gerard P McGlackenSchool of Chemistry & Analytical and Biological Chemistry Research Facility, University College Cork, Cork T12 YN60, Ireland.ORCID 0000-0002-7821-0804

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Ir-catalyzed C-H borylation of fluoroquinolines has been realized. The quinoline boronic ester formed undergoes a range of important transformations of relevance to medicinal chemistry. Judicious choice of the substituent at C4 on the quinoline facilitated the unmasking of a fluoroquinolone─the core structure of many antibiotics.

Indexed as

FluoroquinolonesIridiumBoron CompoundsCatalysisMolecular StructureBoron CompoundsFluoroquinolonesIridium

Identifiers

PMID35839386
PMCPMC9368603

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.