Evidence map›Paper›PMID 35839316›Full record

ArticleClinical and translational medicine2022

Inhibition of the lectin pathway of complement ameliorates hypocomplementemia and restores serum bactericidal activity in patients with severe COVID-19.

Nicholas J Lynch, Andrew C Y Chan, Youssif M Ali, Priyanka Khatri, Ifeoluwa E Bamigbola, Gregory Demopulos, Muriel Paganessi, Alessandro Rambaldi, Wilhelm J Schwaeble

Abstract readLetter
In one paragraph

Article in Clinical and translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
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  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nicholas J LynchDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.ORCID 0000-0003-3803-3329
Andrew C Y ChanDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Youssif M AliDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Priyanka KhatriDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Ifeoluwa E BamigbolaDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.
Gregory DemopulosOmeros Corporation, Seattle, Washington, USA.
Muriel PaganessiUnit of Hematology, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Alessandro RambaldiUnit of Hematology, Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII, Bergamo, Italy.
Wilhelm J SchwaebleDepartment of Veterinary Medicine, University of Cambridge, Cambridge, UK.

Funding

Department of Health COV0170Medical Research Council G0801952Medical Research Council MC_PC_20016
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

COVID-19 Drug TreatmentLectinsComplement C4Complement System ProteinsHumansSerumComplement C4Complement System ProteinsLectins

Identifiers

PMID35839316
PMCPMC9286524

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.