ArticlePLoS biology2022
A Krüppel-like factor is required for development and regeneration of germline and yolk cells from somatic stem cells in planarians.
Article in PLoS biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Regeneration: A planarian DIY fertility restoration guide.Current biology : CB · 2026Article
- Identification of an innexin required for termination of the asexual state in planarian reproductive switching.PLoS genetics · 2025Article
- Establishment and Characteristics of the Spermatogonial Stem Cell Line from the Yellow River Carp (Biology · 2025Article
- Auxin Orchestrates Germ Cell Specification inInternational journal of molecular sciences · 2025Review
- Melastatin family Transient Receptor Potential channels support spermatogenesis in planarian flatworms.The International journal of developmental biology · 2025Article
- The role ofbioRxiv : the preprint server for biology · 2024Article
- A niche-derived nonribosomal peptide triggers planarian sexual development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A transcription factor atlas of stem cell fate in planarians.Cell reports · 2024Article
- The Role ofIntegrative organismal biology (Oxford, England) · 2024Article
- The Ancient Origin and Function of Germline Cysts.Results and problems in cell differentiation · 2024Article
- Female Germline Cysts in Animals: Evolution and Function.Results and problems in cell differentiation · 2024Review
- Review
- A niche-derived non-ribosomal peptide triggers planarian sexual development.bioRxiv : the preprint server for biology · 2023Article
- Evolutionary dynamics of whole-body regeneration across planarian flatworms.Nature ecology & evolution · 2023Article
- Pluripotent, germ cell competent adult stem cells underlie cnidarian regenerative ability and clonal growth.Current biology : CB · 2023Article
- Somatic regulation of female germ cell regeneration and development in planarians.Cell reports · 2022Article
- Articulating the "stem cell niche" paradigm through the lens of non-model aquatic invertebrates.BMC biology · 2022Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Sexually reproducing animals segregate their germline from their soma. In addition to gamete-producing gonads, planarian and parasitic flatworm reproduction relies on yolk cell-generating accessory reproductive organs (vitellaria) supporting development of yolkless oocytes. Despite the importance of vitellaria for flatworm reproduction (and parasite transmission), little is known about this unique evolutionary innovation. Here, we examine reproductive system development in the planarian Schmidtea mediterranea, in which pluripotent stem cells generate both somatic and germ cell lineages. We show that a homolog of the pluripotency factor Klf4 is expressed in primordial germ cells (PGCs), presumptive germline stem cells (GSCs), and yolk cell progenitors. Knockdown of this klf4-like (klf4l) gene results in animals that fail to specify or maintain germ cells; surprisingly, they also fail to maintain yolk cells. We find that yolk cells display germ cell-like attributes and that vitellaria are structurally analogous to gonads. In addition to identifying a new proliferative cell population in planarians (yolk cell progenitors) and defining its niche, our work provides evidence supporting the hypothesis that flatworm germ cells and yolk cells share a common evolutionary origin.
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