ArticlePloS one2022
Common hematological parameters reference intervals for apparently healthy pregnant and non-pregnant women of South Wollo Zone, Amhara Regional State, Northeast Ethiopia.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed.
- Population-based reference intervals for lipid function tests in pregnant and non-pregnant women in Nairobi City, Kenya.Atherosclerosis plus · 2026Article
- Reference Intervals of Hematological Parameters Among Healthy Pregnant Women in Eastern Sudan: A Prospective Longitudinal Cohort Study.International journal of women's health · 2026Article
- Article
- Physiological Changes and Trimester-Specific Reference Intervals for Complete Blood Count Parameters in Korean Pregnant Women.Medicina (Kaunas, Lithuania) · 2025Article
- Evolution of reference intervals for renal-hepatic biomarkers and micronutrients in normal pregnancy during Covid-19 pandemic (2021-2022) in some hospitals of Kinshasa, Democratic Republic of the Congo.Practical laboratory medicine · 2025Article
- Reference intervals for CD4 and hemoglobin among apparently healthy pregnant women in Addis Ababa, Ethiopia.BMC research notes · 2025Article
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Abstract
backgroundHematological reference intervals (RIs) are affected by inherent variables like age, sex, genetic background, environment, diet and certain circumstances such as pregnancy signifying the need for population specific values. This study was designed to establish RIs for common hematological parameters of apparently healthy pregnant and non-pregnant women from Northeast Ethiopia.
methodThis community based cross-sectional study recruited 600 pregnant and non-pregnant women in South Wollo Zone, Northeast Ethiopia from June to August 2019. Complete blood count was performed for eligible participants using Mindary BC-3000 plus hematology analyzer. The mean, median, and 2.5th and 97.5th percentile reference limits with 90% CI were determined using SPSS version 23.
resultThe established selected 2.5th-97.5th percentiles RIs for pregnant women were: WBC: 4.0-13.2x109/L; RBC: 3.45-4.67x1012/L; Hgb: 10.1-13.7g/dL; HCT: 33.5-46.5%; MCV: 85-104fL; MCH: 27.5-33.0pg; MCHC: 30.3-33.7g/dL and Platelet count: 132-373x109/L. The respective values for non-pregnant women were 3.6-10.3; 4.44-5.01; 12.4-14.3; 38.4-50.1; 86-102; 27.1-32.4, 30.4-34.1, 173-456. A statistically significant difference between pregnant and non-pregnant women was noted in all hematological parameters except MCHC. The mean and median value of WBC count, MCV, MPV and PDW increased, whereas mean values of HCT and Platelet count decreased as gestational period advances.
conclusionThe observed difference from other studies signify the necessity for using trimester specific RIs and separate RI for pregnant and non-pregnant women. Thus, we recommend the health facilities in the study area to utilize the currently established RIs for pregnant and non-pregnant women for better care.
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