ArticleAmerican journal of physiology. Heart and circulatory physiology2022
Statistical shape modeling reveals the link between right ventricular shape, hemodynamic force, and myocardial function in patients with repaired tetralogy of Fallot.
Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- Impact of Right Ventricular Surface Area-to-Volume Ratio on Ventricular Remodeling After Pulmonary Valve Replacement.Pediatric cardiology · 2023Trial
- Full-field surrogate modeling of cardiac electrophysiology encoding geometric variability.Computer methods in applied mechanics and engineering · 2026Article
- Discordances in Kinetic Energy Between the Superior Cavopulmonary Connection and Single Ventricle Are Associated With Suboptimal Fontan Outcomes: A Pre-Fontan 4-Dimensional Flow Study.Journal of the American Heart Association · 2025Article
- A 3D Statistical Shape Model of the Right Ventricular Outflow Tract in Pulmonary Valve Replacement Patients Post-Surgical Repair.Journal of cardiovascular development and disease · 2024Article
- Pressure boundary conditions for immersed-boundary methods.Journal of computational physics · 2024Article
- Assessing cardiac mechanics through left ventricular haemodynamic forces.European heart journal. Imaging methods and practice · 2024Review
- Tetralogy of Fallot regurgitation energetics and kinetics: an intracardiac flow analysis of the right ventricle using computational fluid dynamics.The international journal of cardiovascular imaging · 2024Article
- Enhanced echocardiographic assessment of intracardiac flow in congenital heart disease.PloS one · 2024Article
- Intracardiac Flow Analysis of the Right Ventricle in Pediatric Patients With Repaired Tetralogy of Fallot Using a Novel Color Doppler Velocity Reconstruction.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2023Article
- Biventricular shape modes discriminate pulmonary valve replacement in tetralogy of Fallot better than imaging indices.Scientific reports · 2023Article
- Serial RV wall stress measurements: association with right ventricular function in repaired Tetralogy of Fallot patients.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Patients with repaired tetralogy of Fallot (rTOF) can develop chronic pulmonary insufficiency (PI) with right ventricular (RV) dilation, progressive RV dysfunction, and decreased exercise capacity. Pulmonary valve replacement (PVR) can help reduce the amount of PI and RV dilation; however, optimal timing remains controversial; a better understanding of rTOF pathophysiology is of fundamental importance to inform clinical management of patients with rTOF and optimal timing of PVR. In this study, we hypothesize a tight interplay between RV shape, intracardiac biomechanics, and ventricular function in patients with rTOF. To explore this hypothesis and derive quantitative measures, we combined statistical shape modeling with physics-based analysis of in vivo 4D flow data in 36 patients with rTOF. Our study demonstrated for the first time a correlation between regional RV shape variations, hemodynamic forces (HDF), and clinical dysfunction in patients with rTOF. The main findings of this work include
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