Evidence map›Paper›PMID 35838929›Full record

ReviewMolecular biomedicine2022

Significant perspectives on various viral infections targeted antiviral drugs and vaccines including COVID-19 pandemicity.

Gandarvakottai Senthilkumar Arumugam, Kannan Damodharan, Mukesh Doble, Sathiah Thennarasu

Abstract readReview
In one paragraph

Review in Molecular biomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Bisindole Compounds-Synthesis and Medicinal Properties.Antibiotics (Basel, Switzerland) · 2024
    Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Gandarvakottai Senthilkumar Arumugam *Bioengineering and Drug Design Lab, Department of Biotechnology, Indian Institute of Technology Madras (IITM), Chennai, Tamilnadu, 600036, India.
Kannan Damodharan *Bioengineering and Drug Design Lab, Department of Biotechnology, Indian Institute of Technology Madras (IITM), Chennai, Tamilnadu, 600036, India.
Mukesh DobleBioengineering and Drug Design Lab, Department of Biotechnology, Indian Institute of Technology Madras (IITM), Chennai, Tamilnadu, 600036, India. mukesh.doble0@gmail.com.
Sathiah ThennarasuDepartment of Organic and Bioorganic Chemistry, CSIR- Central Leather Research Institute (CLRI), Chennai, Tamilnadu, 600020, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A virus enters a living organism and recruits host metabolism to reproduce its own genome and proteins. The viral infections are intricate and cannot be completely removed through existing antiviral drugs. For example, the herpes, influenza, hepatitis and human immunodeficiency viruses are a few dreadful ones amongst them. Significant studies are needed to understand the viral entry and their growth in host cells to design effective antivirals. This review emphasizes the range of therapeutical antiviral drugs, inhibitors along with vaccines to fight against viral pathogens, especially for combating COVID-19. Moreover, we have provided the basic and in depth information about viral targets, drugs availability, their mechanisms of action, method of prevention of viral diseases and highlighted the significances of anticoagulants, convalescent plasma for COVID-19 treatment, scientific details of airborne transmission, characteristics of antiviral drug delivery using nanoparticles/carriers, nanoemulsions, nanogels, metal based nanoparticles, alike the future nanosystems through nanobubbles, nanofibers, nanodiamonds, nanotraps, nanorobots and eventually, the therapeutic applications of micro- and nanoparticulates, current status for clinical development against COVID-19 together with environmental implications of antivirals, gene therapy etc., which may be useful for repurposing and designing of novel antiviral drugs against various dreadful diseases, especially the SARS-CoV-2 and other associated variants.

Indexed as

Antiviral drugsCOVID-19Drug deliveryNanocarriersVaccinesViral targets

Identifiers

PMID35838929
PMCPMC9283561

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.