Evidence map›Paper›PMID 35838900›Full record

ArticlePurinergic signalling2022

A

Marianna Lovászi, Zoltán H Németh, Pál Pacher, William C Gause, Gebhard Wagener, György Haskó

Open access · greenAbstract read
In one paragraph

Article in Purinergic signalling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Therapeutic potential of CD73Histology and histopathology · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. mBio · 2024
    Article
  13. Review
  14. Adenosine-mediated immune responses in inflammatory bowel disease.Frontiers in cell and developmental biology · 2024
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Marianna LovásziDepartment of Anesthesiology, Columbia University, 622 W. 168th St., P&S Box 46, New York, NY, 10032, USA.
Zoltán H NémethDepartment of Anesthesiology, Columbia University, 622 W. 168th St., P&S Box 46, New York, NY, 10032, USA.
Pál PacherLaboratory of Cardiovascular Physiology and Tissue Injury, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA.
William C GauseDepartment of Medicine and Center for Immunity and Inflammation, New Jersey Medical School, Rutgers Biomedical Health Sciences, Newark, NJ, 07103, USA.
Gebhard WagenerDepartment of Anesthesiology, Columbia University, 622 W. 168th St., P&S Box 46, New York, NY, 10032, USA.
György HaskóDepartment of Anesthesiology, Columbia University, 622 W. 168th St., P&S Box 46, New York, NY, 10032, USA. gh2503@cumc.columbia.edu.
Columbia University · USNational Institute on Alcohol Abuse and Alcoholism · USRutgers, The State University of New Jersey · US

Funding

Purinergic signaling in trauma and sepsisR01GM066189 · NIGMS · UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL · PI HASKO, GEORGE · 2002 to 2020
$4.7M
Neutrophil A2A receptors in sepsisR01HL158519 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HASKO, GEORGE · 2021 to 2024
$2.1M
Purinergic signaling in granuloma-forming Th2 immunityR01DK113790 · NIDDK · RBHS-NEW JERSEY MEDICAL SCHOOL · PI GAUSE, WILLIAM CLARK, HASKO, GEORGE · 2017 to 2020
$1.9M
Becton Dickinson LSR II Analytical Flow CytometerS10RR027050 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CLYNES, RAPHAEL A. · 2011 to 2011
$413k
NCRR NIH HHS S10 RR027050NHLBI NIH HHS R01 HL158519NIDDK NIH HHS R01 DK113790NIGMS NIH HHS R01 GM066189
6 · The paper itself

Abstract

Extracellular adenosine is a biologically active signaling molecule that accumulates at sites of metabolic stress in sepsis. Extracellular adenosine has potent immunosuppressive effects by binding to and activating G protein-coupled A

Indexed as

NeutrophilsSepsisAdenosineAgingAnimalsHumansMiceMice, KnockoutPhenotypeReceptor, Adenosine A2AAdenosineReceptor, Adenosine A2AAdenosine A2A receptorNeutrophil agingNeutrophil polarizationSepsis

Identifiers

PMID35838900
PMCPMC9391554
OpenAlexW4285593005

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.