Evidence map›Paper›PMID 35838820›Full record

ArticleJournal of clinical immunology2022

Algerian Registry for Inborn Errors of Immunity in Children: Report of 887 Children (1985-2021).

Abdelghani Yagoubi, Azzeddine Tahiat, Nabila Souad Touri, Mohamed Samir Ladj, Ouardia Drali, Brahim Belaid, Ayda Mohand-Oussaid, Abdelhak Dehimi, Reda Belbouab, Yacine Ferhani and 37 more

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Article in Journal of clinical immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

47 authors at 11 institutions in 1 country.

Abdelghani YagoubiPediatric Gastroenterology and Digestive Investigations, Centre Algérois de Pédiatrie, 57 Lotissement F, Draria 16050, Algiers, Algeria.
Azzeddine TahiatDepartment of Medical Biology, Rouiba Public Hospital, Rue Larbi Abdesalam 16017, Algiers, Algeria.
Nabila Souad TouriDepartment of Pediatrics, University Hospital Hassiba Ben Bouali, Rue Mohamed Boudiaf 09000, Blida, Algeria.
Mohamed Samir LadjDepartment of Pediatrics, Djilali Belkhenchir Public Hospital, El-Biar, Algiers, Algeria.
Ouardia DraliDepartment of Pediatrics "B", University Hospital Nafissa Hamoud, Rue Boudjemaa Moghni, Hussein Dey 16040, Algiers, Algeria.
Brahim BelaidDepartment of Immunology, University Hospital Issaad Hassani, Beni Messous, 16206, Algiers, Algeria.
Ayda Mohand-OussaidDepartment of Pediatrics "A", University Hospital Issaad Hassani, Beni Messous, 16206, Algiers, Algeria.
Abdelhak DehimiPediatric Division, University Hospital Abdenour Saadna, 19000, Setif, Algeria.
Reda BelbouabDepartment of Pediatrics, University Hospital Mustapha Bacha, Place 1er Mai 1945, Sidi Mhamed, 16024, Algiers, Algeria.
Yacine FerhaniDepartment of Pediatrics, University Hospital Mustapha Bacha, Place 1er Mai 1945, Sidi Mhamed, 16024, Algiers, Algeria.
Souhila MelziDepartment of Pediatrics, University Hospital Lamine Debaghine, Said Touati, Bab el Oued, 16009, BdAlgiers, Algeria.
Assia GuedouarDepartment of Pediatrics "A", University Hospital Nafissa Hamoud, Rue Boudjemaa Moghni, Hussein Dey 16040, Algiers, Algeria.
Saliha HakemDepartment of Pediatrics, University Hospital Mustapha Bacha, Place 1er Mai 1945, Sidi Mhamed, 16024, Algiers, Algeria.
Ouardia KhemiciDepartment of Pediatrics "B", University Hospital Issaad Hassani, Beni Messous, 16206, Algiers, Algeria.
Yacine InouriDepartment of Pediatrics, Central Army Hospital, Ain Naadja 16205, Algiers, Algeria.
Yanis MeddourDepartment of Immunology, Central Army Hospital, Ain Naadja 16205, Algiers, Algeria.
Saadeddine DibDepartment of Pediatrics, University Hospital Dr Tidjani Damerdji, 05, Bd Mohammed V, Tlemcen, Algeria.
Zohra MansouriDepartment of Pediatrics, Ain Taya Public Hospital, Ain Taya, Algiers, Algeria.
Samir IddirDepartment of Pediatrics, University Hospital Nedir Mohamed, Tizi Ouzou, Algeria.
Abderrahmane BoufersaouiDepartment of Pediatrics, Bologhine Ibn Ziri Public Hospital, Rue Aboumoussa El Achaari Hammamet 16060, Algiers, Algeria.
Houda BoudiafDepartment of Pediatric Oncology, University Hospital Mustapha Bacha, Place 1er Mai 1945, Sidi Mhamed, 16024, Algiers, Algeria.
Abderrachid BouhdjilaDepartment of Pediatrics "B", University Hospital Ben Badis, Constantine, Algeria.
Ouardia IbsaineDepartment of Pediatrics, Ain Taya Public Hospital, Ain Taya, Algiers, Algeria.
Hachemi MaoucheDepartment of Pediatrics, Hassen Badi Public Hospital, El-Harrach, Algiers, Algeria.
Djazia DahloukDepartment of Pediatrics, Central Army Hospital, Ain Naadja 16205, Algiers, Algeria.
Azzedine MekkiDepartment of Pediatrics "B", University Hospital Nafissa Hamoud, Rue Boudjemaa Moghni, Hussein Dey 16040, Algiers, Algeria.
Belkacem BioudPediatric Division, University Hospital Abdenour Saadna, 19000, Setif, Algeria.
Zair BouzerarDepartment of Pediatrics, University Hospital Lamine Debaghine, Said Touati, Bab el Oued, 16009, BdAlgiers, Algeria.
Zoulikha ZeroualDepartment of Pediatrics "A", University Hospital Nafissa Hamoud, Rue Boudjemaa Moghni, Hussein Dey 16040, Algiers, Algeria.
Fadila BenhassineDepartment of Pediatrics, Bologhine Ibn Ziri Public Hospital, Rue Aboumoussa El Achaari Hammamet 16060, Algiers, Algeria.
Dahila Bekkat-BerkaniDepartment of Pediatrics, Bologhine Ibn Ziri Public Hospital, Rue Aboumoussa El Achaari Hammamet 16060, Algiers, Algeria.
Soumeya NaamouneDepartment of Immunology, University Hospital Mustapha Bacha, Place 1er Mai 1945, Sidi Mhamed, 16024, Algiers, Algeria.
Samir Sofiane SalahDepartment of Immunology, University Hospital Mustapha Bacha, Place 1er Mai 1945, Sidi Mhamed, 16024, Algiers, Algeria.
Samia ChaibDepartment of Immunology, Central Army Hospital, Ain Naadja 16205, Algiers, Algeria.
Nabila AttalDepartment of Immunology, DelyBrahim, Institut Pasteur d'Alger, Algiers, Algeria.
Nadia BensaadiDepartment of Pediatrics, University Hospital Nedir Mohamed, Tizi Ouzou, Algeria.
Nadira BouchairDepartment of Pediatrics, Clinique Sainte Thérèse, Rue Calama, Annaba, Algeria.
Nacira CherifDepartment of Pediatrics "B", University Hospital Issaad Hassani, Beni Messous, 16206, Algiers, Algeria.
Leila KedjiDepartment of Pediatrics, University Hospital Hassiba Ben Bouali, Rue Mohamed Boudiaf 09000, Blida, Algeria.
Salih BendeddoucheDepartment of Pediatrics, Mother and Child Specialized Hospital, Tlemcen, Algeria.
Mohamed Lamine AtifDepartment of Epidemiology and Preventive Medicine, University Hospital Douera, Douera, Algiers, Algeria.
Kamel DjenouhatDepartment of Medical Biology, Rouiba Public Hospital, Rue Larbi Abdesalam 16017, Algiers, Algeria.
Nadia KechoutDepartment of Immunology, DelyBrahim, Institut Pasteur d'Alger, Algiers, Algeria.
Reda DjidjikDepartment of Immunology, University Hospital Issaad Hassani, Beni Messous, 16206, Algiers, Algeria.
Keltoum Nafissa BenhallaDepartment of Pediatrics "A", University Hospital Issaad Hassani, Beni Messous, 16206, Algiers, Algeria.
Leila SmatiDepartment of Pediatrics, Bologhine Ibn Ziri Public Hospital, Rue Aboumoussa El Achaari Hammamet 16060, Algiers, Algeria.
Rachida BoukariDepartment of Pediatrics, University Hospital Mustapha Bacha, Place 1er Mai 1945, Sidi Mhamed, 16024, Algiers, Algeria. rachida_boukari@yahoo.fr.ORCID 0000-0003-1833-8002
Hôpital Mustapha Pacha · DZUniversity of Algiers Benyoucef Benkhedda · DZCentre Hospitalo-Universitaire Bab El Oued · DZHassiba Benbouali University of Chlef · DZInstitut Pasteur d'Algérie · DZMouloud Mammeri University of Tizi-Ouzou · DZBadji Mokhtar-Annaba University · DZCentre de Recherche Nucléaire d’Alger · DZCentre Hospitalo-Universitaire Dr Benbadis Constantine · DZÉcole Supérieure en Sciences Appliquées de Tlemcen · DZUniversity of Abou Bekr Belkaïd · DZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInborn errors of immunity (IEI) represent a heterogeneous large group of genetic disorders characterized by susceptibility of affected individuals to recurrent infections, autoimmune/inflammatory diseases, allergy, and malignancy. We aimed to report for the first time the Algerian registry for IEI in children.

methodsWe described the characteristics of IEI in Algerian children from the data collected in the Algerian registry for IEI between 1985 and 2021.

resultsOver a period of 37 years, we included 887 children (530 male, 59.6%) with a mean age at diagnosis of 3.23 years and a mean diagnosis delay of 2 years. The prevalence rate was estimated at 1.97/100,000 inhabitants or 5.91/100,000 children. The parental consanguinity was found in 52.6%. The most prevalent category was combined immunodeficiencies (CID) (35.5%), followed by predominantly antibody deficiencies (24.5%) and CID with syndromic features (18.3%). The most predominant diseases were severe CID (134 cases), MHC II deficiency (99 cases), agammaglobulinemia (82 cases), common variable immunodeficiency (78 cases), hyper IgE syndromes (61 patients), ataxia-telangiectasia (46 patients), Wiskott-Aldrich syndrome (40 patients) and chronic granulomatous disease (39 cases). The clinical presentation was dominated by lower respiratory tract infections (69%), failure to thrive (38.3%), and chronic diarrhea (35.2%). Genetic analysis was performed in 156 patients (17.6%). The global mortality rate was 28.4% mainly caused by CID.

conclusionThis is the first report of the Algerian registry for IEI in children. Data is globally similar to that of the Middle East and North African (MENA) registries with high consanguinity, predominance of CID, and significant mortality. This registry highlights the weak points that should be improved in order to provide better patient care.

Indexed as

AgammaglobulinemiaImmunologic Deficiency SyndromesPrimary Immunodeficiency DiseasesAlgeriaChildHumansMaleRegistriesAlgeriaChildrenInborn errors of immunityRegistry

Identifiers

PMID35838820
OpenAlexW4285590521

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.