Evidence map›Paper›PMID 35838799›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2022

The impact of bicuspid aortic valve morphology on von Willebrand factor function in patients with severe aortic stenosis and its change after TAVI.

Nastasia Roth, Carolin Heidel, Congde Xu, Ute Hubauer, Stefan Wallner, Christine Meindl, Andreas Holzamer, Michael Hilker, Marcus Creutzenberg, Samuel Sossalla and 3 more

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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Autoimmune Diseases Affecting Hemostasis: A Narrative Review.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Nastasia RothDepartment of Internal Medicine II, University Medical Center, Regensburg, Germany. nastasia.roth@klinik.uni-regensburg.de.ORCID http://orcid.org/0000-0002-8636-8396
Carolin HeidelDepartment of Internal Medicine II, University Medical Center, Regensburg, Germany.
Congde XuDepartment of Internal Medicine II, University Medical Center, Regensburg, Germany.
Ute HubauerDepartment of Internal Medicine II, University Medical Center, Regensburg, Germany.
Stefan WallnerDepartment of Clinical Chemistry and Laboratory Medicine, University Medical Center, Regensburg, Germany.
Christine MeindlDepartment of Internal Medicine II, University Medical Center, Regensburg, Germany.
Andreas HolzamerDepartment of Cardiothoracic Surgery, University Medical Center, Regensburg, Germany.
Michael HilkerDepartment of Cardiothoracic Surgery, University Medical Center, Regensburg, Germany.
Marcus CreutzenbergDepartment of Anesthesiology, University Medical Center, Regensburg, Germany.
Samuel SossallaDepartment of Internal Medicine II, University Medical Center, Regensburg, Germany.
Lars MaierDepartment of Internal Medicine II, University Medical Center, Regensburg, Germany.
Carsten Jungbauer *Department of Internal Medicine II, University Medical Center, Regensburg, Germany.
Kurt Debl *Department of Internal Medicine II, University Medical Center, Regensburg, Germany.
University Hospital Regensburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAortic stenosis (AS) can cause acquired von Willebrand syndrome (AVWS) and valve replacement has been shown to lead to von Willebrand factor (vWF) recovery. The aim of the current study was to investigate the prevalence of AVWS in different severe AS phenotypes and its course after transcatheter aortic valve implantation (TAVI).

methods143 patients with severe AS undergoing TAVI were included in the study. vWF function was assessed at baseline, 6 and 24 h after TAVI. AVWS was defined as a reduced vWF:Ac/Ag ratio ≤ 0.7. Phenotypes were classified by tricuspid (TAV) and bicuspid (BAV) valve morphology, mean transvalvular gradient (P

resultsAVWS was present in 36 (25.2%) patients before TAVI. vWF:Ac/Ag ratio was significantly lower in high gradient compared to low-gradient severe AS [0.78 (IQR 0.67-0.86) vs. 0.83 (IQR 0.74-0.93), p < 0.05] and in patients with BAV compared to TAV [0.70 (IQR 0.63-0.78) vs. 0.81 (IQR 0.71-0.89), p < 0.05]. Normalization of vWF:Ac/Ag ratio was achieved in 61% patients 24 h after TAVI. As in the overall study cohort, vWF:Ac/Ag ratio increased significantly in all severe AS subgroups 6 h after TAVI (each p < 0.05). Regarding binary logistic regression analysis, BAV was the only significant predictor for AVWS.

conclusionsBAV morphology is a strong predictor for AVWS in severe AS. TAVI restores vWF function in most patients with severe AS independently of AS phenotype and valve morphology.

Indexed as

Aortic Valve StenosisBicuspid Aortic Valve DiseaseTranscatheter Aortic Valve Replacementvon Willebrand DiseasesHumansvon Willebrand Factorvon Willebrand FactorAcquired von Willebrand syndromeAortic stenosisBicuspid aortic valveTranscatheter aortic valve implantationvon Willebrand factor

Identifiers

PMID35838799
PMCPMC9681694
OpenAlexW4285491588

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.