Evidence map›Paper›PMID 35837481›Full record

ReviewFrontiers in aging neuroscience2022

The Role of Exosomes as Mediators of Neuroinflammation in the Pathogenesis and Treatment of Alzheimer's Disease.

Shiting Weng, Qi-Lun Lai, Junjun Wang, Liying Zhuang, Lin Cheng, Yejia Mo, Lu Liu, Zexian Zhao, Ying Zhang, Song Qiao

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Shiting WengThe Second Clinical Medical College, Zhejiang Chinese Medicine University, Hangzhou, China.
Qi-Lun LaiDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Junjun WangDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Liying ZhuangDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Lin ChengDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Yejia MoDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Lu LiuDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Zexian ZhaoDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Ying ZhangDepartment of Neurology, Second Affiliated Hospital of Zhejiang University, Hangzhou, China.
Song QiaoDepartment of Neurology, Zhejiang Hospital, Hangzhou, China.
Zhejiang Hospital · CNSecond Affiliated Hospital of Zhejiang University · CNZhejiang Chinese Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a common neurodegenerative disease characterized by progressive dementia. Accumulation of β-amyloid peptide 1-42 and phosphorylation of tau protein in the brain are the two main pathological features of AD. However, comprehensive studies have shown that neuroinflammation also plays a crucial role in the pathogenesis of AD. Neuroinflammation is associated with neuronal death and abnormal protein aggregation and promotes the pathological process of β-amyloid peptide 1-42 and tau protein. The inflammatory components associated with AD include glial cells, complement system, cytokines and chemokines. In recent years, some researchers have focused on exosomes, a type of membrane nano vesicles. Exosomes can transport proteins, lipids, microRNAs and other signaling molecules to participate in a variety of signaling pathways for signal transmission or immune response, affecting the activity of target cells and participating in important pathophysiological processes. Therefore, exosomes play an essential role in intercellular communication and may mediate neuroinflammation to promote the development of AD. This paper reviews the occurrence and development of neuroinflammation and exosomes in AD, providing a deeper understanding of the pathogenesis of AD. Furthermore, the role of exosomes in the pathogenesis and treatment of AD is further described, demonstrating their potential as therapeutic targets for neuroinflammation and AD in the future.

Indexed as

Alzheimer’s diseasebeta-amyloidexosomesneuroglianeuroinflammationtautherapeutic target

Identifiers

PMID35837481
PMCPMC9273880
OpenAlexW4283655012

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.