Tex264 Binding to SNX27 Regulates Itg

Xiao-Hui Xu, Qian-Wen Yang, Chang-Ling Yue, Yun-Yi Zhu, Zhao-Huan Zhang

Open access · hybridAbstract read

In one paragraph

Article in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 92% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Xiao-Hui Xu *School of Preclinical Medicine, Wannan Medical College, Wuhu 241002, China.ORCID https://orcid.org/0000-0001-7608-4114

Qian-Wen Yang *School of Life Sciences, Shanghai University, Shanghai 200444, China.ORCID https://orcid.org/0000-0003-1875-4372

Chang-Ling Yue *School of Life Sciences, Shanghai University, Shanghai 200444, China.ORCID https://orcid.org/0000-0002-4997-520X

Yun-Yi ZhuSchool of Life Sciences, Shanghai University, Shanghai 200444, China.ORCID https://orcid.org/0000-0002-0365-8946

Zhao-Huan ZhangDepartment of Laboratory Medicine, Changzheng Hospital, Naval Medical University, Shanghai 200003, China.ORCID https://orcid.org/0000-0001-6882-9761

Shanghai University · CNShanghai Changzheng Hospital · CNWannan Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tex264 is an endoplasmic reticulum (ER) membrane protein that was recently demonstrated to act as an ER-phagy receptor under starvation conditions to mediate endoplasmic reticulum autophagy. However, how Tex264 functions in the central nervous system (CNS) and tumors is unclear. Here, we identified 89 proteins from the rat brain that may specifically interact with Tex264 and confirmed the interaction between sorting nexin 27 (SNX27) and Tex264 by coimmunoprecipitation and immunofluorescence. Our results indicated that Tex264 may promote recycling of membrane proteins from endosomes to the cell plasma membrane by recruiting SNX27 retromer vesicles. siRNA-mediated knockdown of TEX264 in HeLa cells did not affect cell proliferation but did significantly inhibit cell migration through a mechanism that may involve a reduction in SNX27-mediated Itg

Indexed as

EndosomesSorting NexinsAnimalsCell MembraneCell MovementEndoplasmic ReticulumHeLa CellsHumansNerve Tissue ProteinsProtein TransportRatsNerve Tissue ProteinsSNX27 protein, humanSnx27 protein, ratSorting Nexins

Identifiers

PMID35837377

DOI10.1155/2022/4304419

PMCPMC9274233

OpenAlexW4283821706

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.