Evidence map›Paper›PMID 35837128›Full record

ArticleFrontiers in neuroscience2022

Probing Neuro-Endocrine Interactions Through Remote Magnetothermal Adrenal Stimulation.

Lisa Y Maeng, Dekel Rosenfeld, Gregory J Simandl, Florian Koehler, Alexander W Senko, Junsang Moon, Georgios Varnavides, Maria F Murillo, Adriano E Reimer, Aaron Wald and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lisa Y MaengDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Dekel RosenfeldResearch Laboratory of Electronics and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Gregory J SimandlDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
Florian KoehlerResearch Laboratory of Electronics and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Alexander W SenkoResearch Laboratory of Electronics and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Junsang MoonResearch Laboratory of Electronics and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Georgios VarnavidesResearch Laboratory of Electronics and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Maria F MurilloDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Adriano E ReimerDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.
Aaron WaldDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
Polina AnikeevaResearch Laboratory of Electronics and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, United States.
Alik S WidgeDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exposure to stressful or traumatic stimuli may alter hypothalamic-pituitary-adrenal (HPA) axis and sympathoadrenal-medullary (SAM) reactivity. This altered reactivity may be a component or cause of mental illnesses. Dissecting these mechanisms requires tools to reliably probe HPA and SAM function, particularly the adrenal component, with temporal precision. We previously demonstrated magnetic nanoparticle (MNP) technology to remotely trigger adrenal hormone release by activating thermally sensitive ion channels. Here, we applied adrenal magnetothermal stimulation to probe stress-induced HPA axis and SAM changes. MNP and control nanoparticles were injected into the adrenal glands of outbred rats subjected to a tone-shock conditioning/extinction/recall paradigm. We measured MNP-triggered adrenal release before and after conditioning through physiologic (heart rate) and serum (epinephrine, corticosterone) markers. Aversive conditioning altered adrenal function, reducing corticosterone and blunting heart rate increases post-conditioning. MNP-based organ stimulation provides a novel approach to probing the function of SAM, HPA, and other neuro-endocrine axes and could help elucidate changes across stress and disease models.

Indexed as

adrenal glandcorticosteroneepinephrinehormonesmagnetic nanoparticlesneuromodulation

Identifiers

PMID35837128
PMCPMC9274974

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.