Evidence map›Paper›PMID 35837011›Full record

ArticleFrontiers in physiology2022

Modulation of Gap Junction Coupling Within the Islet of Langerhans During the Development of Type 1 Diabetes.

Nikki L Farnsworth, Robert A Piscopio, Wolfgang E Schleicher, David G Ramirez, Jose G Miranda, Richard K P Benninger

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Isolated Pancreatic Islet Treatment and Apoptosis Measurement.Journal of visualized experiments : JoVE · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nikki L FarnsworthDepartment of Chemical and Biological Engineering, Colorado School of Mines, Golden, CO, United States.
Robert A PiscopioBarbara Davis Center for Diabetes, Universty of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Wolfgang E SchleicherBarbara Davis Center for Diabetes, Universty of Colorado Anschutz Medical Campus, Aurora, CO, United States.
David G RamirezBarbara Davis Center for Diabetes, Universty of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Jose G MirandaBarbara Davis Center for Diabetes, Universty of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Richard K P BenningerBarbara Davis Center for Diabetes, Universty of Colorado Anschutz Medical Campus, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · US

Funding

University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Emergent Multi-Cellular Properties Regulating Pancreatic Islet FunctionR01DK106412 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Richard KP Benninger · 2015 to 2026
$4.0M
Multicellular Interactions and Dynamics of Pancreatic Islet Function in DiabetesR01DK102950 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI BENNINGER, RICHARD KP · 2015 to 2024
$3.5M
Regulation of islet gap junction coupling and function under inflammatory conditionsF32DK102276 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI FARNSWORTH, NIKKI L. · 2014 to 2016
$169k
Contrast Enhanced Ultrasound with Submicron Nanobubble Contrast Agent Detects Diabetes Progression in Mouse Models of Type 1 DiabetesF31DK121488 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI RAMIREZ, DAVID G · 2019 to 2020
$74k
NIDDK NIH HHS F31 DK121488NIDDK NIH HHS F32 DK102276NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK102950NIDDK NIH HHS R01 DK106412
6 · The paper itself

Abstract

In type 1 diabetes (T1D), islet dysfunction occurs prior to diabetes onset. Pro-inflammatory cytokines can disrupt insulin secretion and Ca

Indexed as

calcium signalingconnexin36cytokinesislet dysfunctionNOD mousetype 1 diabetes

Identifiers

PMID35837011
PMCPMC9274093
OpenAlexW4283650126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.