Evidence map›Paper›PMID 35836942›Full record

ArticleFrontiers in medicine2022

Guillain-Barré Syndrome and Miller Fisher Syndrome in Association With an Arboviral Outbreak: A Brazilian Case Series.

Mateus Santana do Rosário, Pedro Antônio Pereira de Jesus, Daniel Santana Farias, Marco Antônio Caires Novaes, Marcos Vinicius Lima Oliveira Francisco, Cleiton Silva Santos, Daniel Moura, Fernanda Washington de M Lima, Luiz Carlos Junior Alcantara, Isadora Cristina de Siqueira

Abstract read
In one paragraph

Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Frequency of anti-GQ1b IgG antibody in Miller Fisher syndrome: a Chinese single center study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
    Article
  3. Flaviviruses-Induced Neurological Sequelae.Pathogens (Basel, Switzerland) · 2024
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mateus Santana do RosárioInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Pedro Antônio Pereira de JesusSecretaria Estadual da Saúde da Bahia, Hospital Geral Roberto Santos, Salvador, Brazil.
Daniel Santana FariasSecretaria Estadual da Saúde da Bahia, Hospital Geral Roberto Santos, Salvador, Brazil.
Marco Antônio Caires NovaesHospital São Rafael, Fundação Monte Tabor, Salvador, Brazil.
Marcos Vinicius Lima Oliveira FranciscoInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Cleiton Silva SantosInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Daniel MouraFaculdade de Farmácia, Laboratório de Imunologia das Doenças Infecciosas, Universidade Federal da Bahia, Salvador, Brazil.
Fernanda Washington de M LimaFaculdade de Farmácia, Laboratório de Imunologia das Doenças Infecciosas, Universidade Federal da Bahia, Salvador, Brazil.
Luiz Carlos Junior AlcantaraLaboratório de Flavivirus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Isadora Cristina de SiqueiraInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Guillain-Barré syndrome (GBS) in association with arboviruses, such as Zika, chikungunya, and dengue, has been previously documented; however, Miller-Fisher Syndrome (MFS) and other GBS subtypes are rarely reported. Methods: We identified a series of GBS and MFS cases that were followed during the Zika virus outbreak in Salvador, Brazil (2015-2016). Blood and CSF samples were collected for virus diagnosis. In addition, serological studies to verify previous arboviral infection and electromyography (EMG) were performed. Results: Of the 14 patients enrolled, 10 were diagnosed with GBS, including three GBS subtypes (two cases of bifacial weakness with paresthesia and one case of paraparetic GBS), and four as MFS. IgM antibodies against one or more of three arboviruses were present in 11 (78.6%) patients: anti-zika IgM positivity in eight (57%), anti-Chikungunya IgM in three (21%), and anti-Dengue in one (7%) individual. A single case was positive for both anti-Dengue IgM and anti-Chikungunya IgM, suggesting co-infection. EMG revealed an AIDP pattern in all nine patients analyzed. Conclusion: The current case series contributes to our knowledge on the clinical presentation of arbovirus-associated GBS and its subtypes, including MFS, and serves as an alert to clinicians and other healthcare professionals in regions affected by arbovirus outbreaks. We highlight the importance of recognizing arboviruses in diagnosing GBS and its subtypes.

Indexed as

chikungunyadengueGuillain-Barré syndromeMiller Fisher syndromeZika virus

Identifiers

PMID35836942
PMCPMC9274265

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.