ArticleAmerican journal of translational research2022
Analysis of alterations of serum inflammatory cytokines and fibrosis makers in patients with essential hypertension and left ventricular hypertrophy and the risk factors.
Article in American journal of translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Effective Restoration of Gastric and Esophageal Tissues in an In Vitro Model of GERD: Mucoadhesive and Protective Properties of Xyloglucan, Pea Proteins, and Polyacrylic Acid.International journal of molecular sciences · 2025Article
- Clinical and Biological Markers of Frailty Syndrome in Patients Undergoing Elective Percutaneous Coronary Intervention.Diagnostics (Basel, Switzerland) · 2024Article
- New-Onset Atrial Fibrillation in the Critically Ill COVID-19 Patients Hospitalized in the Intensive Care Unit.Journal of clinical medicine · 2023Review
- COVID-19 and atrial fibrillation: Intercepting lines.Frontiers in cardiovascular medicine · 2023Review
- A novel GJA5 variant associated with increased risk of essential hypertension.American journal of translational research · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study mainly analyzed the alterations of serum inflammatory cytokines (ICs) and fibrosis makers in patients with essential hypertension (EH) and the risk factors (RFs).
methodsIn this retrospective study, a total of 145 patients with EH admitted from January 2013 to January 2018 were selected as the research subjects, among which 89 patients without left ventricular hypertrophy (LVH) were included in the EH group and 56 patients with LVH were set as the LVH group. In addition, another 50 healthy subjects who underwent physical examination during the same period were selected as the healthy control (HC) group. The alterations of serum ICs such as interleukin (IL)-6, IL-10 and IL-18, and fibrosis makers like type III procollagen (PCIII), fibronectin (LN) and hyaluronic acid (HA) of the three groups were analyzed, and the RFs of LVH in EH patients were analyzed using the multivariate logistic model.
resultsStatistically higher levels of IL-6, IL-18, PCIII, LN and HA with lower IL-10 levels were determined in the LVH group compared with the EH group. In comparison with the HC group, IL-6, IL-18, PCIII, LN and HA in the EH group were significantly higher, while IL-10 was significantly lower. On the other hand, BMI, LVMI, IL-6, IL-18, PCIII, LN, and HA were identified by multivariate logistic analysis to be the RFs affecting LVH in EH patients, while IL-10 was its protective factor.
conclusionsThe above results suggest that serum ICs (except IL-10) and fibrosis markers are up-regulated abnormally in EH patients with LVH, and BMI, LVMI, IL-6, IL-10, IL-18, PCIII, LN, and HA are all independent predictors of LVH in EH patients.
Indexed as
Identifiers
35836904PMC9274558W4285612588What OpenQuestion holds
Registered trials
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