ReviewFrontiers in pain research (Lausanne, Switzerland)2022
Shifting the Balance: How Top-Down and Bottom-Up Input Modulate Pain
Review in Frontiers in pain research (Lausanne, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Sensory Blurring in Nociplastic Pain: The Role of Descending Inhibitory Dysfunction and Gut-Brain Axis Alterations in Older Adults.Geriatrics (Basel, Switzerland) · 2026Review
- Article
- Brain signatures of nociplastic pain: Fibromyalgia Index and descending modulation at population level.Brain : a journal of neurology · 2026Article
- Mechanisms of the trigeminal-lateral parabrachial-rostroventral medullary circuits involved in experimental occlusal interference induced chronic orofacial pain.The journal of headache and pain · 2026Article
- Deconstruction of a spino-brain-spinal cord circuit drives chronic mechanical pain.Research square · 2025Article
- A sensation driven functional MRI study on brain activation during bladder filling in healthy participants.Scientific reports · 2025Article
- Article
- Opposite effects of isometric exercise on pain sensitivity of healthy individuals: the role of pain modulation.Pain reports · 2024Article
- Startle sign events induced by mechanical manipulation during surgery for neuroma localization: a retrospective cohort study.BMC anesthesiology · 2024Article
- Morphine-responsive neurons that regulate mechanical antinociception.Science (New York, N.Y.) · 2024Article
- Multiple Posterior Insula Projections to the Brainstem Descending Pain Modulatory System.International journal of molecular sciences · 2024Article
- Article
- The 'in's and out's' of descending pain modulation from the rostral ventromedial medulla.Trends in neurosciences · 2024Review
- Towards a Real-Life Understanding of the Altered Functional Behaviour of the Default Mode and Salience Network in Chronic Pain: Are People with Chronic Pain Overthinking the Meaning of Their Pain?Journal of clinical medicine · 2024Review
- Mindfulness intervention effect on endometriosis-related pain dimensions and its mediator role on stress and vitality: a path analysis approach.Archives of women's mental health · 2024Article
- A "double-edged" role for type-5 metabotropic glutamate receptors in pain disclosed by light-sensitive drugs.bioRxiv : the preprint server for biology · 2024Article
- Mechanisms and treatments of chronic pain after traumatic brain injury.Neurochemistry international · 2023Review
- Direct and Indirect Nociceptive Input from the Trigeminal Dorsal Horn to Pain-Modulating Neurons in the Rostral Ventromedial Medulla.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The sensory experience of pain depends not only on the transmission of noxious information (nociception), but on the state of the body in a biological, psychological, and social milieu. A brainstem pain-modulating system with its output node in the rostral ventromedial medulla (RVM) can regulate the threshold and gain for nociceptive transmission. This review considers the current understanding of how RVM pain-modulating neurons, namely ON-cells and OFF-cells, are engaged by "top-down" cognitive and emotional factors, as well as by "bottom-up" sensory inputs, to enhance or suppress pain.
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Registered trials
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