ArticleAnnals of clinical and translational neurology2022
Patterns of hypometabolism in frontal lobe epilepsy originating in different frontal regions.
Article in Annals of clinical and translational neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- Development and validation of interpretable multimodal clinical-radiomics models for predicting epileptogenic foci and surgical outcomes in tuberous sclerosis complex: A multicenter study.PLOS digital health · 2026Article
- Cortical and subcortical morphometric changes in patients with frontal focal cortical dysplasia type II.Neuroradiology · 2025Article
- Predictive model for epileptogenic tubers from all tubers in patients with tuberous sclerosis complex based onBMC medicine · 2023Article
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11 authors at 2 institutions in 1 country.
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Abstract
objectivesAnalysis of FDG-PET imaging commonly shows that hypometabolism extends into extra-epileptogenic zones (extra-EZ). This study investigates the distribution patterns of hypometabolism in frontal lobe epilepsy (FLE) originating in different frontal regions.
methodsSixty-four patients with FLE were grouped by EZ localization according to Brodmann areas (BAs): Group 1 (the frontal motor and premotor area), BAs 4, 6, and 8; Group 2 (the inferior frontal gyrus and opercular area), BAs 44, 45, and 47; Group 3 (the dorsal prefrontal area), BAs 9, 10, 11, and 46; and Group 4 (the medial frontal and anterior cingulate gyrus), BAs 32 and 24. Regions of extra-EZ hypometabolism were statistically analyzed between FLE groups and healthy controls. Correlation analysis was performed to identify relationships between the intensity of hypometabolism and clinical characteristics.
resultsSignificant hypometabolism in the ipsilateral (Groups 1 and 4) or bilateral (Groups 2 and 3) anterior insulae was found. Groups 1 and 4 presented with limited distribution of extra-EZ hypometabolism, whereas Groups 2 and 3 showed widely distributed extra-EZ hypometabolism in the rectus gyrus, cingulate gyrus, and other regions. Additionally, the intensity of hypometabolism was correlated with epilepsy duration in Groups 2 and 3.
conclusionsAll FLE groups showed hypometabolism in the anterior insula. In addition, distinct patterns of extra-EZ hypometabolism were identified for each FLE group. This quantitative FDG-PET analysis expanded our understanding of the topography of epileptic networks and can guide EZ localization in the future.
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