Evidence map›Paper›PMID 35836190›Full record

ArticleJournal of nanobiotechnology2022

Highly sensitive Curcumin-conjugated nanotheranostic platform for detecting amyloid-beta plaques by magnetic resonance imaging and reversing cognitive deficits of Alzheimer's disease via NLRP3-inhibition.

Yuting Ruan, Ying Xiong, Wenli Fang, Qun Yu, Yingren Mai, Zhiyu Cao, Kexi Wang, Ming Lei, Jiaxin Xu, Yan Liu and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yuting Ruan *Department of Rehabilitation Medicine, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Ying Xiong *Department of Medical Ultrasound, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, 510180, China.
Wenli Fang *Department of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Qun YuDepartment of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Yingren MaiDepartment of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China.
Zhiyu CaoDepartment of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Kexi WangDepartment of Thoracic Surgery, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Ming LeiDepartment of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Jiaxin XuDepartment of Neurology, Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, 510120, China.
Yan LiuPaulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA.
Xingcai ZhangPaulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA, 02138, USA. xingcai@mit.edu.
Wang LiaoDepartment of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. liaowang@gzhmu.edu.cn.
Jun LiuDepartment of Neurology, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510260, China. liujun@gzhmu.edu.cn.

Funding

National Natural Science Foundation of China 81870836National Natural Science Foundation of China 82101271Natural Science Foundation of Guangdong Province of China 2020A1515010210Natural Science Foundation of Guangdong Province of China 2020A1515110317
6 · The paper itself

Abstract

backgroundAlzheimer's disease (AD) is the most common neurodegenerative disorder without effective therapy and lack diagnosis strategy for preclinical AD patients. There is an urgent need for development of both early diagnosis and therapeutic intervention of AD.

resultsHerein, we developed a nanotheranostics platform consisting of Curcumin (Cur), an anti-inflammatory molecule, and superparamagnetic iron oxide (SPIO) nanoparticles encapsulated by diblock 1,2-dio-leoyl-sn-glycero-3-phosphoethanolamine-n-[poly(ethylene glycol)] (DSPE-PEG) that are modified with CRT and QSH peptides on its surface. Furthermore, we demonstrated that this multifunctional nanomaterial efficiently reduced β-amyloid plaque burden specifically in APP/PS1 transgenic mice, with the process noninvasively detected by magnetic resonance imaging (MRI) and the two-dimensional MRI images were computed into three-dimension (3D) plot. Our data demonstrated highly sensitive in vivo detection of β-amyloid plaques which more closely revealed real deposition of Aβ than previously reported and we quantified the volumes of plaques for the first time based on 3D plot. In addition, memory deficits of the mice were significantly rescued, probably related to inhibition of NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasomes.

conclusionsGathered data demonstrated that this theranostic platform may have both early diagnostic and therapeutic potential in AD.

Indexed as

Alzheimer DiseaseCurcuminAmyloid beta-PeptidesAnimalsCognitionDisease Models, AnimalMagnetic Resonance ImagingMiceMice, TransgenicNLR Family, Pyrin Domain-Containing 3 ProteinPlaque, AmyloidTheranostic NanomedicineAmyloid beta-PeptidesCurcuminNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mouseAlzheimer's diseaseCurcuminMagnetic resonance imagingNanotheranosticsNLRP3 inflammasome

Identifiers

PMID35836190
PMCPMC9281113

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.