ArticleNature genetics2022
Genetic regulation of OAS1 nonsense-mediated decay underlies association with COVID-19 hospitalization in patients of European and African ancestries.
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Article in Nature genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 107 papers, 5 of them syntheses that pooled it.
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107citing papers in PubMed, 5 pooled it
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Who cites it
107 citing papers in PubMed, 5 syntheses or guidelines pooled it, 135 citations in OpenAlex.
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- Genomic Markers Associated with Cytomegalovirus DNAemia in Kidney Transplant Recipients.Viruses · 2023Pooled it
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- Early Treatment with Pegylated Interferon Lambda for Covid-19.The New England journal of medicine · 2023Trial
- The Neanderthal-Derived 3p21 Haplotype at LZTFL1 in Modern-Day Moroccans Is Associated With COVID-19 Severity and Further Suggests the Presence of Neanderthals in North Africa.International journal of immunogenetics · 2026Article
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- Smoking exposure alters splicing of the nicotinic acetylcholine receptor subunit CHRNA5.Human genomics · 2026Article
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- Advances in haplotype phasing and genotype imputation.Nature reviews. Genetics · 2026Review
- Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza.NPJ digital medicine · 2026Article
- The OAS-RNase L pathway: Insights from experiments of nature.Science immunology · 2026Review
- Innate immune activation and mitochondrial ROS induce acute and persistent cardiac conduction system dysfunction after COVID-19.JCI insight · 2025Article
47 more citing papers are in PubMed but not listed here.
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Authors and funding
70 authors at 20 institutions in 6 countries.
A Rouf Banday *Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Megan L Stanifer *Department of Infectious Diseases, Molecular Virology, University Hospital Heidelberg, Heidelberg, Germany.
Oscar Florez-Vargas *Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-4393-2612
Olusegun O OnabajoLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0001-6342-2380
Brenen W PapenbergLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Muhammad A ZahoorToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-2302-3689
Lisa MirabelloClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Timothy J RingLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-0062-5145
Chia-Han LeeLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Paul S AlbertBiostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Evangelos AndreakosLaboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.ORCID http://orcid.org/0000-0001-5536-1661
Evgeny AronsLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Greg BarshHudsonAlpha Institute for Biotechnology, Huntsville, AL, USA.ORCID http://orcid.org/0000-0002-0838-1042
Leslie G BieseckerCenter for Precision Health Research, National Human Genome Research Institute, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0197-3811
David L BoyleAltman Clinical & Translational Research Institute, UC San Diego Health Sciences, San Diego, CA, USA.
Mark S BrahierGeorgetown University School of Medicine, Washington, DC, USA.
Andrea Burnett-HartmanInstitute for Health Research, Kaiser Permanente Colorado, Aurora, CO, USA.
Mary CarringtonBasic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-2692-2180
Euijin ChangDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-7417-0318
Pyoeng Gyun ChoeDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-6794-7918
Rex L ChisholmCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Leandro M ColliDepartment of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0001-6928-1195
Clifton L DalgardUniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2025-8239
Carolynn M DudeDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Jeff EdbergDepartment of Medicine, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
Nathan ErdmannDepartment of Medicine, Division of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL, USA.
Heather S FeigelsonInstitute for Health Research, Kaiser Permanente Colorado, Aurora, CO, USA.ORCID http://orcid.org/0000-0001-6691-3740
Benedito A FonsecaDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-3159-5687
Gary S FiresteinAltman Clinical & Translational Research Institute, UC San Diego Health Sciences, San Diego, CA, USA.
Adam J GehringToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.ORCID http://orcid.org/0000-0003-1150-5840
Cuncai GuoDivision of Cellular Polarity and Viral Infection, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Michelle HoLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-9143-2241
Steven HollandLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Amy A HutchinsonCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Hogune ImGenome Opinion, Inc., Seoul, Republic of Korea.ORCID http://orcid.org/0000-0002-2812-4617
Les'Shon IrbyDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.
Michael G IsonDivisions of Infectious Diseases and Organ Transplantation, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Naima T JosephDepartment of Obstetrics & Gynecology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Hong Bin KimDepartment of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.ORCID http://orcid.org/0000-0001-6262-372X
Robert J KreitmanLaboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA.
Bruce R KorfDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL, USA.
Steven M LipkinDepartment of Medicine and Program in Mendelian Genetics, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0002-0603-9139
Siham M MahgoubDepartment of Medicine, Infectious Diseases Division, Howard University Hospital, Howard University College of Medicine, Washington, DC, USA.
Iman MohammedFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.
Guilherme L PaschoaliniDepartment of Medical Imaging, Hematology, and Oncology, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil.ORCID http://orcid.org/0000-0003-1623-2466
Jennifer A PachecoCenter for Genetic Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8021-5818
Michael J PelusoDivision of HIV, Infectious Diseases and Global Medicine, University of California, San Francisco, CA, USA.
Daniel J RaderDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-9245-9876
David T ReddenDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, USA.
Marylyn D RitchieDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-1208-1720
Brooke RosenblumCenter for Precision Health Research, National Human Genome Research Institute, Bethesda, MD, USA.
M Elizabeth RossFeil Family Brain and Mind Research Institute, Weill Cornell Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0001-6440-8089
Hanaisa P Sant AnnaLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Sharon A SavageClinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0001-6006-0740
Sudha SharmaDepartment of Biochemistry and Molecular Biology, National Human Genome Center, Howard University College of Medicine, Washington, DC, USA.
Eleni SioutiLaboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.ORCID http://orcid.org/0000-0002-5999-0956
Alicia K SmithDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0002-8537-5156
Vasiliki TriantafylliaLaboratory of Immunobiology, Center for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.ORCID http://orcid.org/0000-0001-5832-4014
Joselin M VargasLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Jose D VargasVeterans Affairs Medical Center, Washington, DC, USA.
Anurag VermaDepartment of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Vibha VijDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
Duane R WesemannDepartment of Medicine, Division of Allergy and Immunology, Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6690-944X
Meredith YeagerCancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID http://orcid.org/0000-0003-3871-2225
Xu YuRagon Institute of MGH, MIT and Harvard, Cambridge, MA, USA.
Yu ZhangLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, Bethesda, MD, USA.
Steeve BoulantDepartment of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL, USA.
Stephen J ChanockLaboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.ORCID http://orcid.org/0000-0002-2324-3393
Jordan J FeldToronto Centre for Liver Disease, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario, Canada.
Ludmila Prokunina-OlssonLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA. prokuninal@mail.nih.gov.ORCID http://orcid.org/0000-0002-9622-2091
National Cancer Institute · USUniversity of Alabama at Birmingham · USAcademy of Athens · GRCornell University · USEmory University · USNorthwestern University · USSeoul National University · KRUniversidade de São Paulo · BRUniversity Health Network · CAUniversity of Pennsylvania · USFrederick National Laboratory for Cancer Research · USGerman Cancer Research Center · DEKaiser Permanente · USNational Human Genome Research Institute · USNational Institute of Allergy and Infectious Diseases · USRagon Institute of MGH, MIT and Harvard · USUC San Diego Health System · USVeterans Health Administration · USBeth Israel Deaconess Medical Center · USBrigham and Women's Hospital · US
Funding
National Dissemination of I-Corps@NCATS: Accelerating Translation through CommercializationUL1TR003096 · NCATS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GUTIERREZ, ORLANDO M, KIMBERLY, ROBERT P. · 2019 to 2023
$43.6MA Resource for Genetic Epidemiology Research in Adult Health and AgingRC2AG036607 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI RISCH, NEIL J., SCHAEFER, CATHERINE ANN · 2009 to 2010
$24.8MGenes And Gene Products As ImmunoadjuvantsZIAAI000647 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI HOLLAND, STEVEN · 2009 to 2025
$22.6MTechnology and Computational CoreP01AI165072 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WESEMANN, DUANE R. · 2021 to 2023
$19.6MRare & Mosaic Disorders - Clinical ResearchZIAHG200388 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI BIESECKER, LESLIE · 2013 to 2025
$17.3MTraining in HIV Translational ResearchT32AI060530 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Diane V Havlir · 2005 to 2026
$6.4MProgenitor Regulation Underlying Cortical Interneuron SpecificationR01NS105477 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI ROSS, MARGARET ELIZABETH · 2018 to 2022
$3.1MMolecular Analysis of RECQ1 Functions in Genome MaintenanceSC1GM093999 · NIGMS · HOWARD UNIVERSITY · PI SHARMA, SUDHA · 2010 to 2019
$3.0MElucidating Germinal Center-Mediated Antibody EvolutionR01AI139538 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI WESEMANN, DUANE R. · 2019 to 2022
$2.4MPatterns of immune response in COVID-19 patientsZIABC011952 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KREITMAN, ROBERT · 2020 to 2025
$1.6MHost genetic resistance to COVID-19ZIABC011949 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI CARRINGTON, MARY N. · 2020 to 2025
$997kCharacterizing the virologic and immunologic signatures of HIV exceptional controlK23AI157875 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PELUSO, MICHAEL JOSEPH · 2021 to 2025
$927kCCR NIH HHS HHSN261200800001CNCATS NIH HHS UL1 TR003096NCI NIH HHS HHSN261200800001ENIAID NIH HHS K23 AI157875NIAID NIH HHS L30 AI147159NIAID NIH HHS P01 AI165072NIAID NIH HHS R01 AI139538NIAID NIH HHS T32 AI060530NIA NIH HHS RC2 AG036607NIGMS NIH HHS SC1 GM093999NINDS NIH HHS R01 NS105477
Abstract
The chr12q24.13 locus encoding OAS1-OAS3 antiviral proteins has been associated with coronavirus disease 2019 (COVID-19) susceptibility. Here, we report genetic, functional and clinical insights into this locus in relation to COVID-19 severity. In our analysis of patients of European (n = 2,249) and African (n = 835) ancestries with hospitalized versus nonhospitalized COVID-19, the risk of hospitalized disease was associated with a common OAS1 haplotype, which was also associated with reduced severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) clearance in a clinical trial with pegIFN-λ1. Bioinformatic analyses and in vitro studies reveal the functional contribution of two associated OAS1 exonic variants comprising the risk haplotype. Derived human-specific alleles rs10774671-A and rs1131454 -A decrease OAS1 protein abundance through allele-specific regulation of splicing and nonsense-mediated decay (NMD). We conclude that decreased OAS1 expression due to a common haplotype contributes to COVID-19 severity. Our results provide insight into molecular mechanisms through which early treatment with interferons could accelerate SARS-CoV-2 clearance and mitigate against severe COVID-19.
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COVID-192',5'-Oligoadenylate SynthetaseAllelesHospitalizationHumansSARS-CoV-22',5'-Oligoadenylate SynthetaseOAS1 protein, human
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