ArticleScientific reports2022
Association of voltage-gated sodium channel mutations with field-evolved pyrethroid resistant phenotypes in soybean aphid and genetic markers for their detection.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 26 citations in OpenAlex.
- Identification and functional validation of glutathione S-transferase genes involved in detoxification of sulfoxaflor, afidopyropen and lambda-cyhalothrin in Aphis glycines.Pest management science · 2026Article
- First Report on Field-Evolved Resistance to Lambda-Cyhalothrin in Rice Leaf Folder (Cnaphalocrocis medinalis Guenee) Populations in Kerala, India: Implications and Concerns of Its Environmental Impact.Environmental toxicology · 2026Article
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- The contribution of transposable element insertions to genetic diversity inbioRxiv : the preprint server for biology · 2025Article
- Spread of a Single Superclone Drives Insecticide Resistance in Acyrthosiphon kondoi Across an Invasive Range.Molecular biology and evolution · 2025Article
- Design, characterization, and evaluation of eco-friendly etofenprox-loaded ethosomes to control Ceratitis capitata (Diptera: Tephritidae).Scientific reports · 2025Article
- Change-point analysis of lambda-cyhalothrin efficacy against soybean aphid (Aphis glycines Matsumura): identifying practical resistance from field efficacy trials.Pest management science · 2022Article
- Evidence of enhanced reproductive performance and lack-of-fitness costs among soybean aphids, Aphis glycines, with varying levels of pyrethroid resistance.Pest management science · 2022Article
- Insights into insecticide-resistance mechanisms in invasive species: Challenges and control strategies.Frontiers in physiology · 2022Review
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8 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The frequent use of insecticides to manage soybean aphids, Aphis glycines (Hemiptera: Aphididae), in the United States has contributed to field-evolved resistance. Pyrethroid-resistant aphids have nonsynonymous mutations in the voltage-gated sodium channel (vgsc). We identified a leucine to phenylalanine mutation at position 1014 (L1014F) and a methionine to isoleucine mutation (M918I) of the A. glycines vgsc, both suspected of conferring knockdown resistance (kdr) to lambda-cyhalothrin. We developed molecular markers to identify these mutations in insecticide-resistant aphids. We determined that A. glycines which survived exposure to a diagnostic concentration of lambda-cyhalothrin and bifenthrin via glass-vial bioassays had these mutations, and showed significant changes in the resistance allele frequency between samples collected before and after field application of lambda-cyhalothrin. Thus, a strong association was revealed between aphids with L1014F and M918I vgsc mutations and survival following exposure to pyrethroids. Specifically, the highest survival was observed for aphids with the kdr (L1014F) and heterozygote super-kdr (L1014F + M918I) genotypes following laboratory bioassays and in-field application of lambda-cyhalothrin. These genetic markers could be used as a diagnostic tool for detecting insecticide-resistant A. glycines and monitoring the geographic distribution of pyrethroid resistance. We discuss how generating these types of data could improve our efforts to mitigate the effects of pyrethroid resistance on crop production.
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