ReviewNature reviews. Disease primers2022
Multimorbidity.
Review in Nature reviews. Disease primers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06855719 (Effectiveness of a Multimodal Intervention With Simulation for Learning Home Health Nursing Care of Patients With Multimorbidity and Heart Failure), which is not on this map. Cited by 820 papers, 11 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effectiveness of a Multimodal Intervention With Simulation for Learning Home Health Nursing Care of Patients With Multimorbidity and Heart Failure: A Randomized Controlled Trial
Who cites it
820 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Multimorbidity and the risk of depression: a systematic review of cohort studies.Journal of global health · 2026Pooled it
- Effectiveness and Implementation of Digital Health Interventions on Physiological, Psychological, and Functional Outcomes in Adults With Multimorbidity: Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of medical Internet research · 2026Pooled it
- Effects of multidomain interventions on health outcomes in older adults: A systematic review and meta-analysis.The journal of nutrition, health & aging · 2026Pooled it
- Is there an association between diabetes and neck and back pain? An updated systematic review with meta-analyses.Chiropractic & manual therapies · 2026Pooled it
- Sex differences in multimorbidity: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Patterns of multimorbidity, their outcomes and analytical methods for their determination: a systematic review.BMC public health · 2026Pooled it
- A systematic scoping review and gap analysis of questionnaires to assess multimorbidity among children.Pediatric research · 2026Pooled it
- Multimorbidity patterns and mental health in late life: a systematic review of longitudinal studies.European geriatric medicine · 2026Pooled it
- Frailty in maintenance hemodialysis: a systematic review and meta-analysis of prevalence and risk factors.International urology and nephrology · 2026Pooled it
- Population attributable fractions of a wide range of peripheral diseases for the burden of dementia.Nature human behaviour · 2026Pooled it
- Perinatal and neonatal outcomes among women with multimorbidity during pregnancy globally: a systematic review.BMC pediatrics · 2026Pooled it
- Multimorbidity patterns influence mobility disability prevention in frail older adults from the SPRINTT trial.Nature aging · 2026Trial
- WhatsApp-Supported Teledentistry to Reinforce Oral Health Promotion Among Older Adults Residing in Rural and Urban Areas: Randomized Controlled Trial.JMIR mHealth and uHealth · 2026Trial
- Associations between continuous health examinations and trajectories of comorbidity of chronic disease: Evidence from a nationwide longitudinal study of middle-aged and older adults in China.Global health research and policy · 2026Article
- Multiple electrolyte imbalances in hospitalized patients: a multimorbidity perspective from a large, retrospective cohort study.Annals of medicine · 2026Article
- Vitamin D deficiency, multimorbidity, and mortality in stage 2 cardiovascular-kidney-metabolic (CKM) Syndrome: evidence from the NHANES 2001-2018 cohort.Renal failure · 2026Article
- Drivers of avoidable emergency department visits in older adults with multiple long-term conditions and palliative care needs: a qualitative survey across six care providers.Scandinavian journal of primary health care · 2026Article
- Multimorbidity and health related quality of life in midlife - a longitudinal study from Northern Finland Birth Cohort 1966.Scandinavian journal of primary health care · 2026Article
- Prioritisation Is Treatment: What Generalists Do When Guidelines Collide.Journal of general internal medicine · 2026Article
- Perceived factors shaping preoperative self-preparation among older patients undergoing total knee arthroplasty: a qualitative study.BMJ open · 2026Article
760 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Multimorbidity (two or more coexisting conditions in an individual) is a growing global challenge with substantial effects on individuals, carers and society. Multimorbidity occurs a decade earlier in socioeconomically deprived communities and is associated with premature death, poorer function and quality of life and increased health-care utilization. Mechanisms underlying the development of multimorbidity are complex, interrelated and multilevel, but are related to ageing and underlying biological mechanisms and broader determinants of health such as socioeconomic deprivation. Little is known about prevention of multimorbidity, but focusing on psychosocial and behavioural factors, particularly population level interventions and structural changes, is likely to be beneficial. Most clinical practice guidelines and health-care training and delivery focus on single diseases, leading to care that is sometimes inadequate and potentially harmful. Multimorbidity requires person-centred care, prioritizing what matters most to the individual and the individual's carers, ensuring care that is effectively coordinated and minimally disruptive, and aligns with the patient's values. Interventions are likely to be complex and multifaceted. Although an increasing number of studies have examined multimorbidity interventions, there is still limited evidence to support any approach. Greater investment in multimorbidity research and training along with reconfiguration of health care supporting the management of multimorbidity is urgently needed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.