ReviewThe Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation2022
Clinical myocardial recovery in advanced heart failure with long term left ventricular assist device support.
Review in The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Application of Artificial Intelligence and Machine Learning in Left Ventricular Assist Device Implantation: A Systematic Review.Artificial organs · 2025Pooled it
- Myocardial recovery in children supported with a durable ventricular assist device-a systematic review.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2023Pooled it
- Surgical Approaches to Left Ventricular Assist Device Deactivation: Lessons From Remission From Stage D Heart Failure.Annals of thoracic surgery short reports · 2026Article
- Acromegalic cardiomyopathy with end-stage heart failure treated with left ventricular assist device: a case report.Journal of medical case reports · 2026Article
- Apical myocardial fibrosis burden identifies a high-risk phenotype and predicts cardiac mortality after LVAD implantation.ESC heart failure · 2026Article
- RDW-to-Albumin Ratio as a Simple Biomarker for Early Mortality Risk After LVAD Implantation.Medicina (Kaunas, Lithuania) · 2026Article
- Heart Replacement Therapy in Young Patients: A Comparative Analysis of HeartMate 3 LVAD and Heart Transplant Using MOMENTUM 3 and UNOS Registry.JACC. Heart failure · 2026Article
- Myocardial Recovery With Mechanical Circulatory Support Is Linked to Alternative Splicing and Subcellular Localization of CAMK2D.Circulation · 2026Article
- Perioperative Care and Clinical Outcomes of Patients with Left Ventricular Assist Devices Undergoing Noncardiac Surgery in Korea: A Retrospective Study.Journal of clinical medicine · 2026Article
- Novel markers of myocardial recovery in patients with left ventricular assist device: A cardiopulmonary exercise test and hemodynamic analysis.JHLT open · 2026Article
- Routine Echocardiographic Assessment in LVAD Patients-A Structured Approach to Acquisition and Interpretation.Journal of cardiovascular development and disease · 2026Review
- Impact of the United Network for Organ Sharing allocation criteria changes on temporary mechanical circulatory support use as a bridge to transplant.World journal of transplantation · 2025Review
- Association of Kidney Function With Myocardial Recovery and Adverse Events Following Left Ventricular Assist Device Circulatory Support.Journal of the American Heart Association · 2025Article
- Chronic kidney disease following left ventricular assist device implantation: contemporary insights and future perspectives.Heart failure reviews · 2025Review
- Effects of Isovolumic Loading Elicited Either by 3-Branch or by 4-Branch Spring Expander on the Degree of Cardiac Atrophy of the Failing Heart in Rats After Heterotopic Heart Transplantation: No Evidence for Sex-Linked Differences.Physiological research · 2025Article
- Role of implantable loop recorders in optimizing care for patients during and after left ventricular assist device support: a single centre experience.BMC cardiovascular disorders · 2025Article
- Article
- A Detailed Weaning Protocol to Assess Cardiac Recovery in Patients With Left Ventricular Assist Devices.JACC. Case reports · 2025Article
- Cardiogenic shock: diagnosis, phenotyping and management.Intensive care medicine · 2025Review
- Apparent End-Stage Heart Failure Forced Toward a Successful Myocardial Recovery.JACC. Case reports · 2025Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Left ventricular assist-device (LVAD) implantation is a life-saving therapy for patients with advanced heart failure (HF). With chronic unloading and circulatory support, LVAD-supported hearts often show significant reverse remodeling at the structural, cellular and molecular level. However, translation of these changes into meaningful cardiac recovery allowing LVAD explant is lagging. Part of the reason for this discrepancy is lack of anticipation and hence promotion and evaluation for recovery post LVAD implant. There is additional uncertainty about the long-term course of HF following LVAD explant. In selected patients, however, guided by the etiology of HF, duration of disease and other clinical factors, significant functional improvement and LVAD explantation with long-term freedom from recurrent HF events has been demonstrated to be feasible in a reproducible manner. The identified predictors of myocardial recovery suggest that the elective therapeutic use of potentially less invasive VADs for reversal of HF earlier in the disease process is a future goal that warrants further investigation. Hence, it is prudent to develop and implement tools to predict HF reversibility prior to LVAD implant, optimize unloading-promoted recovery with guideline directed medical therapy and monitor for myocardial improvement. This review article summarizes the clinical aspects of myocardial recovery and together with its companion review article focused on the biological aspects of recovery, they aim to provide a useful framework for clinicians and investigators.
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