ArticleBrain & development2022
Severe encephalopathy associated with SARS-CoV-2 Omicron BA.1 variant infection in a neonate.
Article in Brain & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Cross-Section of Neurological Manifestations Among SARS-CoV-2 Omicron Subvariants-Single-Center Study.Brain sciences · 2024Article
- Specific convulsions and brain damage in children hospitalized for Omicron BA.5 infection: an observational study using two cohorts.World journal of pediatrics : WJP · 2024Observational
- The influence of Omicron on vaccine efficacy and durability: a neurology perspective.Clinical and experimental vaccine research · 2024Review
- Complexity and Diversity of the Neurological Spectrum of SARS-CoV-2 over Three Waves of COVID-19.Journal of clinical medicine · 2024Article
- Viral entry and translation in brain endothelia provoke influenza-associated encephalopathy.Acta neuropathologica · 2024Article
- COVID-19 among infants: key clinical features and remaining controversies.Clinical and experimental pediatrics · 2024Article
- Neurological complications during the Omicron COVID-19 wave in China: A cohort study.European journal of neurology · 2024Article
- Intranasal infection by SARS-CoV-2 Omicron variants can induce inflammatory brain damage in newly weaned hamsters.Emerging microbes & infections · 2023Article
- Neurological disorders associated with COVID-19 in Sri Lanka.BMC neurology · 2023Article
- SARS-CoV-2 Omicron variant causes brain infection with lymphoid depletion in a mouse COVID-19 model.Laboratory animal research · 2023Article
- Impact of perinatal COVID on fetal and neonatal brain and neurodevelopmental outcomes.Seminars in fetal & neonatal medicine · 2023Review
- SARS-CoV-2 Infection of Young Infants during the Omicron Wave: A Case Series.Biomedicine hub · 2023Article
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe coronavirus disease 2019 (COVID-19), including the Omicron variant, is less severe in children than in adults. To date, there has been no detailed description of COVID-19-associated severe encephalopathy due to the Omicron variant during the neonatal and early infantile periods. CASE PRESENTATION: During the outbreak of the Omicron variant, a 29-day-old male presented with a pale and ill appearance. The patient was intubated for mechanical ventilation owing to recurrent apnea, which subsequently turned out to be a breath-holding that may have been caused by seizure. In addition, nonconvulsive status epilepticus was observed. Total duration of repetitive seizure activities was approximately 30 min per hour when seizures were most severe. Brain magnetic resonance imaging (MRI) on day 14 revealed extensive hyperintensity in the T2 sequence, hypointensity in the fluid-attenuated inversion recovery (FLAIR) sequence in the deep and subcortical white matter, and diffusion restriction in the corpus callosum. The Omicron BA.1 variant of the severe acute respiratory syndrome coronavirus 2 was detected in his respiratory sample. Follow-up MRI on day 45 revealed multiple cystic cavitations.
conclusionAlthough COVID-19 is not severe in most children, life-threatening conditions such as COVID-19-associated severe encephalopathy can occur during the neonatal and early infantile periods.
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