Evidence map›Paper›PMID 35835563›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2022

Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis.

Rikke Holm Hansen, Jacob Talbot, Helene Højsgaard Chow, Malene Bredahl Hansen, Sophie Buhelt, Sebastian Herich, Nicholas Schwab, Marie Nathalie Nickelsen Hellem, Joergen Erik Nielsen, Finn Sellebjerg and 1 more

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In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Rikke Holm HansenFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark. rikke.holm.hansen@regionh.dk.ORCID 0000-0001-8729-6075
Jacob TalbotFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-6803-2207
Helene Højsgaard ChowFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-2032-2755
Malene Bredahl HansenFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-2006-3503
Sophie BuheltFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-3199-6720
Sebastian HerichFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-8976-7811
Nicholas SchwabFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-5494-9885
Marie Nathalie Nickelsen HellemFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.
Joergen Erik NielsenFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0003-0453-5582
Finn SellebjergFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0002-1333-9623
Marina Rode von EssenFrom the Danish Multiple Sclerosis Center (R.H.H.H., J.T., H.H.C., M.B.H., S.B., F.S., M.R.E.), Department of Neurology, Copenhagen University Hospital-Rigshospitalet, Glostrup, Denmark; Department of Neurology with Institute of Translational Neurology (S.H., N.S.), University Hospital Münster, Albert-Schweitzer-Campus 1, Germany; Department of Clinical Medicine (F.S.), Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; and Neurogenetics Clinic (M.N.N.H., J.E.N.), Danish Dementia Research Center, Rigshospitalet, Copenhagen, Denmark.ORCID 0000-0001-9367-5020
University of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesFollicular helper T (Tfh) cells play a critical role in protective immunity helping B cells produce antibodies against foreign pathogens and are likely implicated in the pathogenesis of various autoimmune diseases. The purpose of this study was to investigate the role of Tfh cells in the pathogenesis of multiple sclerosis (MS).

methodsUsing flow cytometry, we investigated phenotype, prevalence, and function of Tfh cells in blood and CSF from controls and patients with relapsing-remitting MS (RRMS) and primary progressive MS (PPMS). In addition, an in vitro blood-brain barrier coculture assay of primary human astrocytes and brain microvascular endothelial cells grown in a Boyden chamber was used to assess the migratory capacity of peripheral Tfh cells.

resultsThis study identified 2 phenotypically and functionally distinct Tfh cell populations: CD25 DISCUSSION: Our study indicates substantial changes in intrathecal Tfh dynamics, particularly in patients with RRMS, and suggests that the intrathecal inflammatory environment in patients with RRMS promotes recruitment of peripheral Tfh cells rather than the Tfh cells having an increased capacity to migrate to CNS.

Indexed as

Multiple SclerosisMultiple Sclerosis, Relapsing-RemittingB-LymphocytesEndothelial CellsHumansT Follicular Helper Cells

Identifiers

PMID35835563
PMCPMC9621607
OpenAlexW4285494421

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.