ReviewJournal of the American College of Cardiology2022
Contributions of the Women's Health Initiative to Cardiovascular Research: JACC State-of-the-Art Review.
Abstract readReview
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Review in Journal of the American College of Cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
–field-weighted citation impact
What it found
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The trial behind it
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Who cites it
21 citing papers in PubMed.
- Indoor Radon Concentrations and Hematologic Traits in the Women's Health Initiative.Epidemiology (Cambridge, Mass.) · 2026Article
- Quantifying Evidence for Competing Biomedical Hypotheses using Large Language Models and Bayesian Analysis.bioRxiv : the preprint server for biology · 2026Article
- Greater amounts of visceral adipose and lean body mass increase heart failure risk in older women.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- Plasma proteomics link menopause timing to brain aging and dementia risk.Research square · 2026Article
- Plasma proteomics link menopause timing to brain aging and dementia risk.medRxiv : the preprint server for health sciences · 2026Article
- Inflammaging and Cardiovascular Risk in Old Women.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Review
- Muscular Strength and Mortality in Women Aged 63 to 99 Years.JAMA network open · 2026Article
- Long-term systemic outcomes of postmenopausal hormone replacement therapy by age at menopause: a real-world cohort study.Human reproduction open · 2026Article
- A Review of Traditional and Non-Traditional Cardiovascular Risk Factors in Women.International journal of women's health · 2026Review
- Pregnancy and breastfeeding are associated with less later-life cognitive decline in a longitudinal, prospective cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Bidirectional Associations Between Obesity and Depressive Symptoms: Results From the Multiethnic Postmenopausal Cohort of the Women's Health Initiative Study.The American journal of geriatric psychiatry. Open science, education, and practice · 2025Article
- Impact of exercise on the 21Sports medicine and health science · 2025Review
- Protein quantitative trait locus analysis in African American and non-Hispanic White individuals.Genome biology · 2025Article
- Improving Cardiovascular Clinical Competencies for the Menopausal Transition: A Focus on Cardiometabolic Health in Midlife.JACC. Advances · 2025Article
- Sedentary behaviors and venous thromboembolism risk among older women: the Objective Physical Activity and Cardiovascular Health study.Journal of thrombosis and haemostasis : JTH · 2025Article
- Maternal cardiovascular research and education should be prioritized in the United States.American journal of physiology. Heart and circulatory physiology · 2025Article
- Precision pharmacology in menopause: advances, challenges, and future innovations for personalized management.Frontiers in reproductive health · 2025Review
- National Institute on Aging's 50th anniversary: Advancing aging research and the health and well-being of older adults.Journal of the American Geriatrics Society · 2024Article
- Article
- Quantifying structural racism in cohort studies to advance prospective evidence.SSM - population health · 2023Article
Corrections and comments
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Authors and funding
22 authors.
Michael J LaMonteDepartment of Epidemiology and Environmental Health, University at Buffalo-SUNY, Buffalo, New York, USA. Electronic address: mlamonte@buffalo.edu.
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Garnet L AndersonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Laura D BakerDepartment of Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Jennifer W BeaDepartment of Health Promotion Science, University of Arizona, Tucson, Arizona, USA.
Charles B EatonDepartment of Family Medicine and Epidemiology, Brown University, Providence, Rhode Island, USA.
Shawna FollisStanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California, USA.
Kathleen M HaydenDepartment of Social Sciences and Health Policy, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Andrea Z LaCroixDivision of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, California, USA.
Marian C LimacherDepartment of Internal Medicine, University of Florida, Gainesville, Florida, USA.
Marian L NeuhouserDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Andrew OdegaardDepartment of Epidemiology, University of California, Irvine, California, USA.
Marco V PerezDepartment of Medicine, Stanford University, Palo Alto, California, USA.
Ross L PrenticeDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, Washington, USA.
Marcia L StefanickStanford Prevention Research Center, Department of Medicine, Stanford University, Stanford, California, USA.
Linda Van HornDepartment of Preventive Medicine, Northwestern University, Chicago, Illinois, USA.
Gretchen L WellsDepartment of Medicine, University of Alabama, Birmingham, Alabama, USA.
Eric A WhitselDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA.
Jacques E RossouwNational Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
WHI Investigators
Funding
WOMEN'S HEALTH INITIATIVE - CLINICAL COORDINATING CENTER: TASK AREA B - LONG LIFE STUDY VISIT 2 LIMITED HOME VISIT75N92021D00001 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ANDERSON, GARNET L. · 2021 to 2025
$52.0MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC): TASK AREA A AND A275N92021D00002 · NHLBI · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI WACTAWSKI-WENDE, JEAN · 2021 to 2025
$6.9MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00004 · NHLBI · STANFORD UNIVERSITY · PI STEFANICK, MARCIA · 2021 to 2025
$6.5MWomen's Health Initiative Sleep Hypoxia Effects on Resilience (WHISPER)R01HL133684 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAKER, LAURA D. · 2017 to 2020
$6.5MPhysical Activity to Improve CV Health in Older Women: A Pragmatic TrialR33HL151885 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI KOOPERBERG, CHARLES L, LACROIX, ANDREA Z. · 2021 to 2023
$6.4MObjective Physical Activity and Cardiovascular Health in Older Women: OPACH2R01HL153462 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LACROIX, ANDREA Z., LAMONTE, MICHAEL J · 2022 to 2025
$6.2MClonal hematopoiesis in the Womens Health Initiative Memory StudyR01HL148565 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ALEXANDER P REINER, Eric A. Whitsel · 2019 to 2026
$5.9MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00003 · NHLBI · OHIO STATE UNIVERSITY · PI JACKSON, REBECCA · 2021 to 2025
$5.0MObjective Physical Activity and Cardiovascular Health in Women Aged 80 and OlderR01HL105065 · NHLBI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI LACROIX, ANDREA Z. · 2011 to 2014
$5.0MWOMEN'S HEALTH INITIATIVE (WHI) REGIONAL CENTER (RC) - TO EXERCISE OPTION PERIOD ONE (1) AND REVISE CONTRACT ARTICLES.75N92021D00005 · NHLBI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI VITOLINS, MARA · 2021 to 2025
$4.2MCocoa Supplement and Multivitamin Outcomes Study in the Mind (COSMOS-Mind)R01AG050657 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI BAKER, LAURA D., ESPELAND, MARK ANDREW · 2016 to 2020
$3.8MWHISH-2-Prevent Heart Failure StudyR01HL130591 · NHLBI · MEMORIAL HOSPITAL OF RHODE ISLAND · PI EATON, CHARLES B · 2016 to 2020
$3.1MNHLBI NIH HHS 75N92021D00001NHLBI NIH HHS 75N92021D00002NHLBI NIH HHS HHSN268201100046CNHLBI NIH HHS R01 HL105065NHLBI NIH HHS R01 HL130591NHLBI NIH HHS R01 HL133684NHLBI NIH HHS R01 HL148565NHLBI NIH HHS R01 HL150170NHLBI NIH HHS R01 HL153462NHLBI NIH HHS R33 HL151885NHLBI NIH HHS R61 HL151885NIA NIH HHS R01 AG050657WHI NIH HHS 75N92021D00003WHI NIH HHS 75N92021D00004WHI NIH HHS 75N92021D00005
Abstract
The WHI (Women's Health Initiative) enrolled 161,808 racially and ethnically diverse postmenopausal women, ages 50-79 years, from 1993 to 1998 at 40 clinical centers across the United States. In its clinical trial component, WHI evaluated 3 randomized interventions (menopausal hormone therapy; diet modification; and calcium/vitamin D supplementation) for the primary prevention of major chronic diseases, including cardiovascular disease, in older women. In the WHI observational study, numerous clinical, behavioral, and social factors have been evaluated as predictors of incident chronic disease and mortality. Although the original interventions have been completed, the WHI data and biomarker resources continue to be leveraged and expanded through ancillary studies to yield novel insights regarding cardiovascular disease prevention and healthy aging in women.
Indexed as
Cardiovascular DiseasesAgedCalciumFemaleHormone Replacement TherapyHumansMiddle AgedObservational Studies as TopicUnited StatesVitamin DWomen's HealthCalciumVitamin Dcardiovascular diseaseepidemiologymenopausepreventionrandomized trialwomen’s health
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.