ArticleNeuroImage2022
Assessing pulsatile waveforms of paravascular cerebrospinal fluid dynamics within the glymphatic pathways using dynamic diffusion-weighted imaging (dDWI)
Article in NeuroImage, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Glymphatic Pathway Dysfunction in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis Using Diffusion Tensor Imaging Along the Perivascular Space.CNS neuroscience & therapeutics · 2025Pooled it
- TRACC-PHYSIO: Time-Domain Resolution-Aligned Cross-Correlation to Estimate PHYSIOlogical Coupling and Time Delays in Dynamic MRI.Magnetic resonance in medicine · 2026Article
- Non-invasive characterization of perivascular subarachnoid spaces.Nature communications · 2026Article
- Regional Cerebrospinal Fluid Motility as a Key Determinant of Soluble Amyloid-β Levels and Kinetics.Research square · 2026Article
- Simultaneous Assessment of Intracranial Artery and Paravascular CSF Pulsation Using 3D Whole-Brain Diffusion-Prepared Cine bSSFP (DECAF) MRI.Magnetic resonance in medicine · 2026Article
- Moving Past Tonsil Position: Craniocervical Junction Crowding Shapes Cerebrospinal Fluid Effective Motility in Chiari I Malformation.medRxiv : the preprint server for health sciences · 2026Article
- Rapid Tissue-CSF Water Exchange in the Human Brain Revealed by Magnetization Transfer Indirect Spin Labeling.Magnetic resonance in medicine · 2026Article
- Mapping subarachnoid cerebrospinal fluid circulation in the human brain.bioRxiv : the preprint server for biology · 2026Article
- The glymphatic system and glioblastoma.Brain : a journal of neurology · 2026Review
- New integrated three-interface conceptual model for clearance and immune surveillance in the human CNS.Frontiers in cell and developmental biology · 2026Review
- Dynamic DWI detects respiratory modulation of brain parenchymal hydrodynamics.Imaging neuroscience (Cambridge, Mass.) · 2026Article
- A CSF Background Suppression Scheme in Arterial Spin Labeling MRI.NMR in biomedicine · 2026Article
- Cerebrospinal fluid mechanics across CNS barriers: from production, circulation, and clearance to mechanomedicine.Frontiers in neuroscience · 2026Review
- Imaging the therapeutic effects of cerebral endothelial cell derived exosome treatment of a preclinical model of Alzheimer's disease.Frontiers in aging neuroscience · 2026Article
- Imaging blood to periarterial CSF flow coupling using 4D flow MRI and an ultra-high-performance head-only gradient system.Fluids and barriers of the CNS · 2025Article
- Quantitative evaluation of low-frequency oscillations using real-time phase-contrast MRI during drowsiness.Fluids and barriers of the CNS · 2025Article
- Region-specific drivers of CSF mobility measured with MRI in humans.Nature neuroscience · 2025Article
- HyPER: Region-specific hypersampling of fMRI to resolve low-frequency, respiratory, and cardiac pulsations, revealing age-related differences.NeuroImage · 2025Article
- Relaxation-Selective Intravoxel Incoherent Motion Imaging of Microvascular Perfusion and Fluid Compartments in the Human Choroid Plexus.NMR in biomedicine · 2025Article
- Feasibility of Observing Glymphatic System Activity During Sleep Using Diffusion Tensor Imaging Analysis Along the Perivascular Space (DTI-ALPS) Index.Diagnostics (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Cerebrospinal fluid (CSF) in the paravascular spaces of the surface arteries (sPVS) is a vital pathway in brain waste clearance. Arterial pulsations may be the driving force of the paravascular flow, but its pulsatile pattern remains poorly characterized, and no clinically practical method for measuring its dynamics in the human brain is available. In this work, we introduce an imaging and quantification framework for in-vivo non-invasive assessment of pulsatile fluid dynamics in the sPVS. It used dynamic Diffusion-Weighted Imaging (dDWI) at a lower b-values of 150s/mm
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.