Trial reportOphthalmology2022
Treatment Outcomes in the Primary Tube Versus Trabeculectomy Study after 5 Years of Follow-up.
Trial report in Ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
61 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does standalone phacoemulsification lower intraocular pressure in glaucomatous eyes? A systematic review and meta-analysis.Eye (London, England) · 2025Pooled it
- Ahmed and baerveldt in glaucoma surgery: what is the safest choice? - a systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.JAMA ophthalmology · 2025Trial
- Comparison of postoperative cyclosporine 2.0% versus betamethasone 0.1% eye drops following trabeculectomy: A randomized clinical trial.Indian journal of ophthalmology · 2025Trial
- Visual Field Outcomes in the Primary Tube Versus Trabeculectomy Study.Ophthalmology · 2024Trial
- Outcomes of Glaucoma Reoperations in the Primary Tube Versus Trabeculectomy Study.Ophthalmology. GlaucomaTrial
- Win Ratios in Ophthalmology-a Hierarchical Metric to Evaluate Adverse Outcomes in Comparative Studies.Ophthalmology science · 2026Article
- Clinical outcomes of Preserflo MicroShunt implant procedure in open‑angle glaucoma patients - a 1000 eyes case-series; including subanalysis of combined cataract-glaucoma surgery and standalone surgery in pseudophakic eyes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Risk-Stratified Interventional Management and Surgical Decision-Making in Primary Glaucoma.Biomedicines · 2026Review
- Corneal tomography and endothelial cell density after Paul glaucoma implant surgery.Acta ophthalmologica · 2026Article
- Association between capsulectomy shunt revision and Ahmed glaucoma valve implant exposure--Shanghai Ahmed glaucoma valve implant exposure (AGVIE) study.BMC ophthalmology · 2026Article
- Clinical Outcomes and Risk Factors for Surgical Failure Following Baerveldt Glaucoma Implant Surgery as a Primary Filtering Procedure.Journal of clinical medicine · 2026Article
- Increased Risk of Intraocular Pressure-Lowering Treatment in Patients with End-Stage Renal Disease Undergoing Hemodialysis.Ophthalmology. Glaucoma · 2026Article
- Factors influencing the long-term-success of the XEN gel stent.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Preserflo MicroShunt in refractory glaucoma: multicentre european results with up to three years of follow-up.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- A-stream glaucoma shunt versus trabeculectomy: 1-year results on efficacy and safety.Scientific reports · 2026Article
- New Insights into Glaucoma-An Editorial Review on Broadening Risk Assessment, Refining Surgical Strategy, and Standardizing Clinical Practice.Journal of clinical medicine · 2026Article
- Ab Interno Minimally Invasive Glaucoma Surgery Effectiveness in Black Patients: An IRIS Registry Study.Journal of glaucoma · 2026Observational
- Prospective Pilot Study of Sustained Release Bimatoprost Implant with SpyGlass Intraocular Lens: 3-Year Results.Ophthalmology and therapy · 2026Article
- Preserflo microshunt in a real-life UK tertiary setting: success rates, safety profile, and postoperative management.International ophthalmology · 2026Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
purposeTo report 5-year treatment outcomes in the Primary Tube Versus Trabeculectomy (PTVT) Study.
designMulticenter randomized clinical trial.
participantsA total of 242 eyes of 242 patients with medically uncontrolled glaucoma and no previous incisional ocular surgery, including 125 patients in the tube group and 117 patients in the trabeculectomy group.
methodsPatients were enrolled at 16 clinical centers and randomly assigned to treatment with a tube shunt (350-mm
main outcome measuresThe primary outcome measure was the rate of surgical failure, defined as intraocular pressure (IOP) > 21 mmHg or reduced < 20% from baseline, IOP ≤ 5 mmHg, reoperation for glaucoma, or loss of light perception. Secondary outcome measures included IOP, glaucoma medical therapy, and visual acuity.
resultsThe cumulative probability of failure after 5 years of follow-up was 42% in the tube group and 35% in the trabeculectomy group (P = 0.21; hazard ratio = 1.31; 95% confidence interval = 0.86-2.01). At 5 years, IOP (mean ± standard deviation) was 13.4 ± 3.5 mmHg in the tube group and 13.0 ± 5.2 mmHg in the trabeculectomy group (P = 0.52), and the number of glaucoma medications (mean ± standard deviation) was 2.2 ± 1.3 in the tube group and 1.3 ± 1.4 in the trabeculectomy group (P < 0.001).
conclusionsTrabeculectomy with MMC and tube shunt surgery produced similar IOPs after 5 years of follow-up in the PTVT Study, but fewer glaucoma medications were required after trabeculectomy. No significant difference in the rate of surgical failure was observed between the 2 surgical procedures at 5 years.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.